CAJ | 학술논문

目的：探讨奥卡西平（OXC）和丙戊酸钠（VPA）对癫痫患者血浆同型半胱氨酸（Hcy）和不对称二甲基精氨酸（AD-MA）水平的影响。方法分别检测 OXC 组32例和 VPA 组36例单药治疗的癫痫患者血浆 Hcy 和 ADMA 水平，与对照组比较，并分析 Hcy 和 ADMA 水平与抗癫痫药物治疗时间的相关性。结果 OXC 组和 VPA 组患者血 Hcy、ADMA 水平高于对照组（P ＜0．05），OXC 组和 VPA 组比较，差异无统计学意义（P ＞0．05）；抗癫痫药治疗时间与血浆 Hcy、ADMA 水平均呈正相关（r ＝0．274、0．256，P ＜0．05）。结论 OXC 和 VPA 可引起癫痫患者血浆 Hcy、ADMA 水平升高，长期服用 OXC 和 VPA 的癫痫患者应监测血 Hcy、ADMA，及时补充 B 族维生素、叶酸有利于减少血栓事件的发生。
목적：탐토오잡서평（OXC）화병무산납（VPA）대전간환자혈장동형반광안산（Hcy）화불대칭이갑기정안산（AD-MA）수평적영향。방법분별검측 OXC 조32례화 VPA 조36례단약치료적전간환자혈장 Hcy 화 ADMA 수평，여대조조비교，병분석 Hcy 화 ADMA 수평여항전간약물치료시간적상관성。결과 OXC 조화 VPA 조환자혈 Hcy、ADMA 수평고우대조조（P ＜0．05），OXC 조화 VPA 조비교，차이무통계학의의（P ＞0．05）；항전간약치료시간여혈장 Hcy、ADMA 수평균정정상관（r ＝0．274、0．256，P ＜0．05）。결론 OXC 화 VPA 가인기전간환자혈장 Hcy、ADMA 수평승고，장기복용 OXC 화 VPA 적전간환자응감측혈 Hcy、ADMA，급시보충 B 족유생소、협산유리우감소혈전사건적발생。
Objective To investigate plasma homocysteine(Hcy)and asymmetric dimethyl arginine(ADMA)concentration in patients with epilepsy receiving oxcarbazepine(OXC)or sodium valproate(VPA)monotherapy.Methods Plasma were collected from 32 cases of OXC and 36 cases of VPA monotherapy.The levels of hcy and ADMA were detected and compared with healthy controls.Then the correlation of the levels and antiepileptic drug treatment duration was analyzed.Results The levels of hcy and ADMA in treatment groups were higher than in control gruops(P <0.05),and no difference between two treatment groups(P >0.05).Antiepileptic drug treatment duration and plasma Hcy,ADMA levels were positively correlated (r =0.274,P <0.05;r =0.256,P <0.05).Conclusion OXC and VPA elevated hcy and ADMA plasma levels in patients with epilepsy.Routine monitoring of plasma hcy and ADMA and supplementation of B vitamins and folate acid might have help to reduce thrombotic events occurring for patients receiving long-term OXC and VPA therapy.