CAJ | 학술논문

目的：检测2型糖尿病肿瘤患者血浆中胰岛素样生长因子‐1（IG F‐1）水平，并与糖尿病患者、健康人作对比，探讨2型糖尿病患者血浆IG F‐1检测筛查早期恶性肿瘤的意义。方法分别测定2型糖尿病肿瘤组、2型糖尿病组及健康对照组的血浆IGF‐1水平。结果2型糖尿病组、2型糖尿病肿瘤组的血浆IGF‐1水平明显低于健康对照组（P＜0．05），而2型糖尿病肿瘤组的血浆IGF‐1水平明显高于2型糖尿病组（P＜0．05）。血浆IGF‐1、空腹静脉血糖（FBG）、HbA1c及负荷后2 h静脉血糖（2hBG）水平是肿瘤的危险因素，基础胰岛素（FIns）水平是肿瘤发生的保护因素。结论2型糖尿病与恶性肿瘤密切相关，血浆IGF‐1水平是肿瘤的危险因素。
목적：검측2형당뇨병종류환자혈장중이도소양생장인자‐1（IG F‐1）수평，병여당뇨병환자、건강인작대비，탐토2형당뇨병환자혈장IG F‐1검측사사조기악성종류적의의。방법분별측정2형당뇨병종류조、2형당뇨병조급건강대조조적혈장IGF‐1수평。결과2형당뇨병조、2형당뇨병종류조적혈장IGF‐1수평명현저우건강대조조（P＜0．05），이2형당뇨병종류조적혈장IGF‐1수평명현고우2형당뇨병조（P＜0．05）。혈장IGF‐1、공복정맥혈당（FBG）、HbA1c급부하후2 h정맥혈당（2hBG）수평시종류적위험인소，기출이도소（FIns）수평시종류발생적보호인소。결론2형당뇨병여악성종류밀절상관，혈장IGF‐1수평시종류적위험인소。
Objective To test plasma insulin‐like growth factor 1(IGF‐1) level in type 2 diabetic patients with malignant tumor , and make comparison with diabetic patients and normal patients .To discuss the significance of detection of plasma IGF‐1 level in type 2 diabetes in screening early malignant tumor .Methods Plasma IGF‐1 level were determined in type 2 diabetes among malig‐nant tumor group ,type 2 diabetes ,and normal control group ,and statistical comparison was made between the three groups .Results the plasma levels of IGF‐1 of type 2 diabetes mellitus ,type 2 diabetes mellitus with malignant tumor were significantly lower than normal group(P<0 .05) .And the plasma level of IGF‐1 in type 2 diabetes mellitus with malignant tumor group was obviously high‐er than that of type 2 diabetic group(P<0 .05) .Plasma IGF‐1 ,FBG ,HbA1c and 2 HBG level are risk factors for tumor .The level of FIns is a protective factor for tumor .Conclusion Type 2 diabetes is closely related to the malignant tumor ,and the plasma levels of IGF‐1 is a risk factor for tumor .