CAJ | 학술논문

目的：考察促泌素（SCGN）和嗜铬粒蛋白A（CgA）在胰腺神经内分泌肿瘤的表达。方法选择2007年10月至2013年10月到该院住院治疗并行手术的胰腺神经内分泌肿瘤（PNETs）患者共54例，采用免疫组织化学法检测肿瘤标本中SCGN、CgA的表达情况。结果54例胰腺神经内分泌肿瘤标本均有SCGN和CgA表达。在非功能性PNETs、肿瘤体积大于30 cm3、有包膜、侵犯血管和淋巴结转移中，SCGN较CgA高（P＜0．05）。在功能性PNETs、不同肿瘤部位、肿瘤体积小于或等于30 cm3、无包膜、无侵犯血管和淋巴结转移中SCGN和CgA表达差异无统计学意义（P＞0．05）。结论将PNETs形态学改变，肿瘤侵犯包膜、血管，局部组织浸润，淋巴结及脏器转移等病理参数，结合SCGN与CgA 在肿瘤组织的表达可综合评估 PNETs的恶性程度。
목적：고찰촉비소（SCGN）화기락립단백A（CgA）재이선신경내분비종류적표체。방법선택2007년10월지2013년10월도해원주원치료병행수술적이선신경내분비종류（PNETs）환자공54례，채용면역조직화학법검측종류표본중SCGN、CgA적표체정황。결과54례이선신경내분비종류표본균유SCGN화CgA표체。재비공능성PNETs、종류체적대우30 cm3、유포막、침범혈관화림파결전이중，SCGN교CgA고（P＜0．05）。재공능성PNETs、불동종류부위、종류체적소우혹등우30 cm3、무포막、무침범혈관화림파결전이중SCGN화CgA표체차이무통계학의의（P＞0．05）。결론장PNETs형태학개변，종류침범포막、혈관，국부조직침윤，림파결급장기전이등병리삼수，결합SCGN여CgA 재종류조직적표체가종합평고 PNETs적악성정도。
Objective To investigate the expression of secretagogin(SCGN) and chromogranin A(CgA) in pancreatic neuroen‐docrine tumors (PNETs) .Methods Totally 54 cases of PNETs hospitalized in our hospital from October 2007 to October 2013 were enrolled in our study .Immunohistochemical detection was used to determine secretagogin and CgA .Results Secretagogin and CgA were highly expressed in all PNETs specimens .Compared with CgA ,secretagogin were highly expressed in the non‐functional PNETs ,tumor volume>30 cm3 ,the enveloped ,vascular invasion and lymph node metastasis (P<0 .05) .There were no statistically significant difference between SCGN and CgA in functional PNETs tumor volume ≤30 cm3 ,no enveloped ,no vascular invasion and lymph node metastasis(P>0 .05) .Conclusion The expression of secretagogin and CgA in tumor combined with PNETs pathologi‐cal characteristics can predict the severity of PNETs .