CAJ | 학술논문

目的：采用新型合成法制备磷霉素氨丁三醇，研究其合成工艺条件和析晶条件。方法无机酸式盐法，以磷霉素钠与氨丁三醇和硫酸的混合酸式盐进行中和反应制得磷霉素氨丁三醇。结果优化反应和结晶条件后可生成磷霉素氨丁三醇。结论无机酸式盐法合成工艺可行，收率高。
목적：채용신형합성법제비린매소안정삼순，연구기합성공예조건화석정조건。방법무궤산식염법，이린매소납여안정삼순화류산적혼합산식염진행중화반응제득린매소안정삼순。결과우화반응화결정조건후가생성린매소안정삼순。결론무궤산식염법합성공예가행，수솔고。
Objective to investigate a new synthesis for the preparation of fosfomycin tromethamine and to seek for the opti‐mized process and crystallization conditions .Methods An inorganic method ,utilizing in situ generated tromethamine bisulfate to re‐act with fosfomycin sodium was used to gain fosfomycin tromethamine .Results After the optimization of reaction and crystalliza‐tion condition ,it can produce fosfomycin tromethamine .Conclusion Inorganic acid salt synthesis technology is feasible with high yield .