CAJ | 학술논문

目的：检测系统性红斑狼疮（SLE）患者外周血中CXCL9表达水平并探讨其临床意义。方法采用ELISA法检测20例SLE患者（试验组）和20例健康对照者（对照组）外周血CXCL9表达水平。比较CXCL9在两组血清中表达的差异，分析CXCL9与SLE患者年龄、病程及SLE病情活动指数（SLEDAI）的相关性。结果试验组和对照组外周血CXCL9水平分别为（1549．14±362．74）pg／L和（602．54±83．70）pg／L。经统计学分析，试验组外周血CXCL9水平明显高于对照组，差异有统计学意义（P＜0．01）；试验组外周血CXCL9水平与SLEDAI评分呈正相关（r＝0．892，P＜0．01）。结论 CXCL9可能参与了SLE的发病过程。
목적：검측계통성홍반랑창（SLE）환자외주혈중CXCL9표체수평병탐토기림상의의。방법채용ELISA법검측20례SLE환자（시험조）화20례건강대조자（대조조）외주혈CXCL9표체수평。비교CXCL9재량조혈청중표체적차이，분석CXCL9여SLE환자년령、병정급SLE병정활동지수（SLEDAI）적상관성。결과시험조화대조조외주혈CXCL9수평분별위（1549．14±362．74）pg／L화（602．54±83．70）pg／L。경통계학분석，시험조외주혈CXCL9수평명현고우대조조，차이유통계학의의（P＜0．01）；시험조외주혈CXCL9수평여SLEDAI평분정정상관（r＝0．892，P＜0．01）。결론 CXCL9가능삼여료SLE적발병과정。
Objective To investigate the expression and significance of CXCL 9 in systemic lupus erythematosus (SLE ) . Methods The level of CXCL9 in peripheral blood from 20 patients with SLE and 20 normal controls were measured by enzyme linked immunosorbent assay .Compare the difference of the expression level of CXCL 9 in peripheral blood between two groups and analyzed their correlation with ages ,duration ,SLE diseases activity index (SLEDAI) .Results The level of CXCL9 in peripheral blood in patients with systemic lupus erythematosus was (1 549 .14 ± 362 .74)pg/L ,but in normal controls was(602 .54 ± 83 .70)pg/L .The level of CXCL9 in peripheral blood in patients with systemic lupus erythematosus was obviously higher than that in controls by statistical analysis ,there was significant difference between the two groups (P<0 .01) .The expression level of CXCL9 in pe‐ripheral blood of patients with systemic lupus erythematosus was positively correlated with SLEDAI (r=0 .892 ,P<0 .01) .Conclu‐sion CXCL9 may be involved in the pathogenesis of systemic lupus erythematosus .