CAJ | 학술논문

目的：观察舒乐洗剂治疗外阴阴道念珠菌病（VVC）的效果。方法建立体外白念珠菌生物膜模型，采用 XTT 法检测生物膜抑制率；建立 VVC 小鼠模型，采用阴道涂片检查和病理组织检测法，比较给药前后炎症状况的变化。结果舒乐洗剂对体外白念珠菌生物膜的形成有明显抑制作用，并成一定的剂量依赖性；能够抑制体外白念珠菌菌落形成，其中原液稀释一倍的效果最为显著；能够明显减少小鼠体内白念珠菌菌落形成，并能够减少炎性细胞向阴道黏膜的浸润。结论舒乐洗剂具有体外抗生物膜形成的作用，并能降低体内小鼠白念珠菌的感染状况，减轻VVC 小鼠阴道黏膜炎症，从而达到治疗 VVC 的作用。
목적：관찰서악세제치료외음음도념주균병（VVC）적효과。방법건입체외백념주균생물막모형，채용 XTT 법검측생물막억제솔；건립 VVC 소서모형，채용음도도편검사화병리조직검측법，비교급약전후염증상황적변화。결과서악세제대체외백념주균생물막적형성유명현억제작용，병성일정적제량의뢰성；능구억제체외백념주균균락형성，기중원액희석일배적효과최위현저；능구명현감소소서체내백념주균균락형성，병능구감소염성세포향음도점막적침윤。결론서악세제구유체외항생물막형성적작용，병능강저체내소서백념주균적감염상황，감경VVC 소서음도점막염증，종이체도치료 VVC 적작용。
Objective To observe the effect of Shule lotion in the treatment of vulvovaginal candidiasis(VVC), Methods The study established the candida albicans biofilm model in vitro,testing the inhibition rate of biological membrane by XTT method;the rat model of VVC was established,by the method of vaginal smear examination and histopathology,compa_ring to the changes of inflammatory status before and after drug administration, Results Shule lotion had inhibition effects on candida albicans biofilm formation in vitro,and in a dose dependent manner,which could inhibit the formation of candida albi_cans colony, And that the solution was diluted twice had the most significant effect,which could obviously reduce the colony for_mation of candida albicans in mice,and it ccould reduce inflammatory cell infiltrating to the vaginal mucosa, Conclusion Shule lotion has inhibition effects on candida albicans biofilm formation in vitro,and can reduce the infection status of candida albicans in vivo,and reduce the VVC mouse vaginal mucosa imflammation,so it may be the mechanism for Shule lotion treating VVC.