CAJ | 학술논문

目的：探讨小剂量喹硫平治疗失眠的疗效。方法：将80例失眠患者随机分为研究组(喹硫平组)和对照组(阿普唑仑组)，两组分别给予喹硫平、阿普唑仑治疗，采用睡眠障碍量表(SDRS)于治疗前及治疗后1、2、3周评定临床疗效，使用症状量表(TESS)评定治疗中出现的不良反应。结果：两组治疗后 SDRS 评分均较治疗前显著下降(P＜0.01)。治疗前后两组疗效差异无统计学意义(P＞0.05)。两组不良反应均较轻。结论：小剂量喹硫平治疗失眠症患者疗效显著，两组不良反应均较轻，无明显差异。
목적：탐토소제량규류평치료실면적료효。방법：장80례실면환자수궤분위연구조(규류평조)화대조조(아보서륜조)，량조분별급여규류평、아보서륜치료，채용수면장애량표(SDRS)우치료전급치료후1、2、3주평정림상료효，사용증상량표(TESS)평정치료중출현적불량반응。결과：량조치료후 SDRS 평분균교치료전현저하강(P＜0.01)。치료전후량조료효차이무통계학의의(P＞0.05)。량조불량반응균교경。결론：소제량규류평치료실면증환자료효현저，량조불량반응균교경，무명현차이。
Objective:To explore the curative effect of small dose quetiapine in the treatment of insomnia.Methods:80 patients with insomnia were randomly divided into the study group(quetiapine group) and the control group(alprazolam group).Two groups were respectively given quetiapine and alprazolam.Before treatment and 1,2,3 weeks after treatment,the clinical curative effects were evaluated by using sleep dysfunction rating scale(SDRS).The adverse reactions in the treatment were evaluated by treatment emergent symptom scale(TESS).Results:SDRS scores of two groups after treatment were significantly lower than before treatment(P<0.01).The effect of two groups before and after treatment had no significant difference(P>0.05).The adverse reactions of two groups were mild.Conclusion:Small dose quetiapine in the treatment of patients with insomnia has significant effect.Adverse reactions of two groups are mild.It is no obvious difference.