CAJ | 학술논문

目的：分析探讨雷替曲塞联合奥沙利铂治疗晚期胃癌的疗效及安全性。方法50例胃癌患者随机分为两组，观察组25例采用雷替曲塞联合奥沙利铂化疗方案；对照组25例采用奥沙利铂+亚叶酸钙+5-氟尿嘧啶化疗方案。比较两组疗效。结果观察组总有效率和疾病控制率均高于对照组，两组比较差异有统计学意义(P<0.05)；观察组与对照组不良反应发生率分别为24.0%和32.0%，差异无统计学意义(P>0.05)；两组未见因不良反应延缓化疗的患者，且无化疗相关性死亡。结论雷替曲塞联合奥沙利铂治疗晚期胃癌临床疗效较好，是治疗晚期胃癌的一种较好的联合化疗方案，值得临床使用。
목적：분석탐토뢰체곡새연합오사리박치료만기위암적료효급안전성。방법50례위암환자수궤분위량조，관찰조25례채용뢰체곡새연합오사리박화료방안；대조조25례채용오사리박+아협산개+5-불뇨밀정화료방안。비교량조료효。결과관찰조총유효솔화질병공제솔균고우대조조，량조비교차이유통계학의의(P<0.05)；관찰조여대조조불량반응발생솔분별위24.0%화32.0%，차이무통계학의의(P>0.05)；량조미견인불량반응연완화료적환자，차무화료상관성사망。결론뢰체곡새연합오사리박치료만기위암림상료효교호，시치료만기위암적일충교호적연합화료방안，치득림상사용。
Objective To analyze and investigate the curative effect and safety of raltitrexed combined with oxaliplatin in the treatment of advanced gastric cancer. Methods A total of 50 patients with gastric cancer were randomly divided into two groups. The observation group with 25 cases received raltitrexed combined with oxaliplatin for chemotherapy;the control group with 25 cases was treated by oxaliplatin+calcium folinate+5-flu-orouracil for chemotherapy. Curative effects were compared between the two groups. Results The total effective rate and disease control rate were all higher in the observation group than in the control group, and the difference between the two groups had statistical significance (P<0.05). The incidences of adverse reactions were respectively 24.0%and 32.0%in the observation group and the control group, and the difference was not statistically signifi-cant (P>0.05). There was no patient with suspended chemotherapy due to adverse reactions, or related death case with chemotherapy. Conclusion The combination of raltitrexed and oxaliplatin has good clinical effect in the treatment of advanced gastric cancer. It is a remarkable combined chemotherapy method for advanced gastric can-cer, and is worthy of clinical application.