CAJ | 학술논문

目的：了解降钙素原在重症肺炎中的诊断价值。方法46例重症肺炎患者为实验组，另选取同期体查的46例健康体检者为对照组，均于1 d内行血常规、C-反应蛋白、降钙素原、体温测定，并从血清降钙素原水平出发，将实验组进行分级(包括≥10.0μg/L组、<0.5μg/L组、≥2.0~10.0μg/L组、≥0.5~2.0μg/L组)，观察各组呼吸机应用状况、病死情况及住院时间与抗生素使用时间。结果实验组C-反应蛋白、降钙素原显著高于对照组(P<0.05)，中性粒细胞百分比、白细胞计数、体温对比差异无统计学意义(P>0.05)；降钙素原水平与重症肺炎患者住院时间、呼吸机应用次数、抗生素使用时间具有相关性(P<0.05)。结论降钙素原在重症肺炎临床诊断与病情评估中具有重要的指导价值，在临床上应引起足够重视。
목적：료해강개소원재중증폐염중적진단개치。방법46례중증폐염환자위실험조，령선취동기체사적46례건강체검자위대조조，균우1 d내행혈상규、C-반응단백、강개소원、체온측정，병종혈청강개소원수평출발，장실험조진행분급(포괄≥10.0μg/L조、<0.5μg/L조、≥2.0~10.0μg/L조、≥0.5~2.0μg/L조)，관찰각조호흡궤응용상황、병사정황급주원시간여항생소사용시간。결과실험조C-반응단백、강개소원현저고우대조조(P<0.05)，중성립세포백분비、백세포계수、체온대비차이무통계학의의(P>0.05)；강개소원수평여중증폐염환자주원시간、호흡궤응용차수、항생소사용시간구유상관성(P<0.05)。결론강개소원재중증폐염림상진단여병정평고중구유중요적지도개치，재림상상응인기족구중시。
Objective To understand the diagnostic value of procalcitonin in severe pneumonia. Methods A total of 46 severe pneumonia patients were selected as experimental group, and 46 healthy people at the same period were chosen as control group. They all received blood routine examination, detection of C-reactive protein, procalcitonin, and body temperature within 1 d. The experimental group was classified by procalcitonin level (as≥10.0μg/L group,<0.5μg/L group,≥2.0~10.0μg/L group, and≥0.5~2.0μg/L group). Application of breathing machine, fatality state, hospital stays, and antibiotics use time were observed in all the groups. Results The experimental group had obviously higher levels of C-reactive protein and procalcitonin than the control group (P<0.05). The differences of neutrophile granulocyte percentage, white blood cell count, and body temperature had no statistical significance (P>0.05). The level of procalcitonin had a correlation with hospital stays, application times of breathing machine, and antibiotics use times of the severe pneumonia patients (P<0.05).Conclusion Procalcitonin has important guiding value in clinical diagnosis and disease assessment of severe pneumonia, and it ought to be paid with enough attention in clinic.