重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
4期
482-484
,共3页
唐瑛%孙长岗%刘永%王海英%王占聚
唐瑛%孫長崗%劉永%王海英%王佔聚
당영%손장강%류영%왕해영%왕점취
血小板减少%螺杆菌幽门%儿童%淋巴细胞亚群%血小板相关抗体
血小闆減少%螺桿菌幽門%兒童%淋巴細胞亞群%血小闆相關抗體
혈소판감소%라간균유문%인동%림파세포아군%혈소판상관항체
thrombocytopenia%helicobacter pylori%child%lymphocyte subsets%platelet associated immunoglobulin
目的:探讨免疫性血小板减少症(IT P)患儿感染幽门螺杆菌(Hp)的特点及抗感染治疗的意义。方法采用13 C尿素呼气试验检测142例ITP患儿和92例健康儿童Hp感染情况。将ITP患儿中97例阳性者分为两组:联合治疗组49例,应用糖皮质激素联合抗 H p治疗;单药治疗组48例,单用糖皮质激素治疗。分别检测两组治疗前后血小板相关参数、血小板相关抗体和淋巴细胞亚群的变化。结果 IT P患儿 Hp的感染率为69.7%,明显高于健康儿童(40.2%)。两组患儿治疗6个月后,联合治疗组患儿血小板计数、PCT、CD3+、CD3+CD4+和CD3+ CD4+/CD3+ CD8+升高水平明显高于单药治疗组(P<0.01),而MPV、PDW、PAIgG、PAIgA、CD3+CD8+下降水平均高于单药治疗组(P<0.01)。结论 ITP患儿 Hp感染率高于健康儿童;Hp可能通过影响机体免疫功能参与了儿童ITP的发病和发展过程,联合抗 Hp治疗可改善ITP患儿机体免疫状态,提高治疗效果。
目的:探討免疫性血小闆減少癥(IT P)患兒感染幽門螺桿菌(Hp)的特點及抗感染治療的意義。方法採用13 C尿素呼氣試驗檢測142例ITP患兒和92例健康兒童Hp感染情況。將ITP患兒中97例暘性者分為兩組:聯閤治療組49例,應用糖皮質激素聯閤抗 H p治療;單藥治療組48例,單用糖皮質激素治療。分彆檢測兩組治療前後血小闆相關參數、血小闆相關抗體和淋巴細胞亞群的變化。結果 IT P患兒 Hp的感染率為69.7%,明顯高于健康兒童(40.2%)。兩組患兒治療6箇月後,聯閤治療組患兒血小闆計數、PCT、CD3+、CD3+CD4+和CD3+ CD4+/CD3+ CD8+升高水平明顯高于單藥治療組(P<0.01),而MPV、PDW、PAIgG、PAIgA、CD3+CD8+下降水平均高于單藥治療組(P<0.01)。結論 ITP患兒 Hp感染率高于健康兒童;Hp可能通過影響機體免疫功能參與瞭兒童ITP的髮病和髮展過程,聯閤抗 Hp治療可改善ITP患兒機體免疫狀態,提高治療效果。
목적:탐토면역성혈소판감소증(IT P)환인감염유문라간균(Hp)적특점급항감염치료적의의。방법채용13 C뇨소호기시험검측142례ITP환인화92례건강인동Hp감염정황。장ITP환인중97례양성자분위량조:연합치료조49례,응용당피질격소연합항 H p치료;단약치료조48례,단용당피질격소치료。분별검측량조치료전후혈소판상관삼수、혈소판상관항체화림파세포아군적변화。결과 IT P환인 Hp적감염솔위69.7%,명현고우건강인동(40.2%)。량조환인치료6개월후,연합치료조환인혈소판계수、PCT、CD3+、CD3+CD4+화CD3+ CD4+/CD3+ CD8+승고수평명현고우단약치료조(P<0.01),이MPV、PDW、PAIgG、PAIgA、CD3+CD8+하강수평균고우단약치료조(P<0.01)。결론 ITP환인 Hp감염솔고우건강인동;Hp가능통과영향궤체면역공능삼여료인동ITP적발병화발전과정,연합항 Hp치료가개선ITP환인궤체면역상태,제고치료효과。
Objective To explore the clinic character of immune thrombocytopenia (ITP) children infected with helicobacter py‐lori (Hp) and the effects of anti‐helicobacter pylori treatment on those children .Methods One hundred and forty‐two ITP children and 92 healthy children were conducted the 13C‐Urea breath test to determine the infections of Hp .The ITP children infected with Hp were divided into two groups :single drug group (48 cases ,treated only with corticosteroid ) and combined drugs group (49 ca‐ses ,treated with corticosteroid and anti‐helicobacter pylori treatment) .The platelet parameters ,platelet associated immunoglobulin and some lymphocyte subsets were analyzed .Results Ninety seven children infected with Hp were found in 142 ITP children (69 . 7% ) .In the mean time ,37 children infected with Hp were observed in 92 healthy children (40 .2% ) .After treatment of 6 months , the PLT ,PCT ,CD3+ ,CD3+CD4+ and CD3+ CD4+ /CD3+ CD8+ of ITP children in both group were increased ,and the increased degree of those parameters were much higher in combined drug group than those in single drug group (P< 0 .01) .However ,the MPV ,PDW ,PAIgG ,PAIgA and CD3+ CD8+ were more decreased than that of the single drug group(P<0 .01) .Conclusion The ITP children have a higher infection rate of Hp ,which may be involved in the pathogenesis of ITP .Anti‐helicobacter pylori therapy would improve the therapy efficacy of ITP children infected with Hp by improving their immunity .