广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2015年
4期
51-52,58
,共3页
陆加明%陈灵%刘阳%戴赞群%方玲佳%王巧丽%陈定奔
陸加明%陳靈%劉暘%戴讚群%方玲佳%王巧麗%陳定奔
륙가명%진령%류양%대찬군%방령가%왕교려%진정분
吡唑并吡啶类化合物%合成%条件筛选%2 ,2-二溴乙烯基苯%一锅法
吡唑併吡啶類化閤物%閤成%條件篩選%2 ,2-二溴乙烯基苯%一鍋法
필서병필정류화합물%합성%조건사선%2 ,2-이추을희기분%일과법
pyrazolopyridine%synthesis%screening conditions%2,2-dibromo(phenyl)ethene%“One-pot” method
以苯甲醛出发合成2,2-二溴乙烯基苯；此外,从吡啶出发,和羟胺-O-磺酸反应得到碘化-1-氨基吡啶。然后以2,2-二溴乙烯基苯和碘化-1-氨基吡啶作为原料,在乙醇钠的催化作用下,合成了3-溴-2-苯基-1氢-吡唑并[1,5-a]吡啶并加以结构表征；我们对该反应进行了条件筛选,选出最佳条件,产率达到34.6%。
以苯甲醛齣髮閤成2,2-二溴乙烯基苯；此外,從吡啶齣髮,和羥胺-O-磺痠反應得到碘化-1-氨基吡啶。然後以2,2-二溴乙烯基苯和碘化-1-氨基吡啶作為原料,在乙醇鈉的催化作用下,閤成瞭3-溴-2-苯基-1氫-吡唑併[1,5-a]吡啶併加以結構錶徵；我們對該反應進行瞭條件篩選,選齣最佳條件,產率達到34.6%。
이분갑철출발합성2,2-이추을희기분；차외,종필정출발,화간알-O-광산반응득도전화-1-안기필정。연후이2,2-이추을희기분화전화-1-안기필정작위원료,재을순납적최화작용하,합성료3-추-2-분기-1경-필서병[1,5-a]필정병가이결구표정；아문대해반응진행료조건사선,선출최가조건,산솔체도34.6%。
2,2-dibromo(phenyl)ethane was synthesized from benzaldehyde, 1-Aminopyridinium Iodide was derived from Pyridine and hydroxylamine-O-sulfonic acid. With 2,2-dibromo(phenyl)ethane and 1-Aminopyridinium Iodide as raw material, 3-bromo-2-pheny-1H-pyrazolo [1,5-a] pyridine in ethanol under the effect of sodium and characterized the structure was synthesized. The condition was selected, of the reaction was screened, the best condition and the yield of product was up to 34.6%.
