CAJ | 학술논문

目的：探讨细胞毒性T淋巴细胞相关抗原-4(CTLA-4)基因多态性与福建地区汉族重症肌无力(MG)患者的相关性。方法：PCR扩增、限制性片断长度多态性方法检测福建地区重症肌无力患者CTLA-4基因外显子1区的+49A/G位点多态性。结果：MG组和对照组的49A/G位点的基因型和等位基因比较均无统计学意义，MG组与CTLA-4的+49A/G多态性之间无明显联系(P>0.05)。但是MG组+49A/G位GG和非GG基因型比较有性别差异(字2GG=4.41，P=0.04)，男性患者的GG基因型频率多于女性患者。结论：在福建地区CTLA-4的外显子1区的+49A/G位点基因可能不参与MG的发病。
목적：탐토세포독성T림파세포상관항원-4(CTLA-4)기인다태성여복건지구한족중증기무력(MG)환자적상관성。방법：PCR확증、한제성편단장도다태성방법검측복건지구중증기무력환자CTLA-4기인외현자1구적+49A/G위점다태성。결과：MG조화대조조적49A/G위점적기인형화등위기인비교균무통계학의의，MG조여CTLA-4적+49A/G다태성지간무명현련계(P>0.05)。단시MG조+49A/G위GG화비GG기인형비교유성별차이(자2GG=4.41，P=0.04)，남성환자적GG기인형빈솔다우녀성환자。결론：재복건지구CTLA-4적외현자1구적+49A/G위점기인가능불삼여MG적발병。
Objective:To investigate the relevance of CTLA-4 exon region 49A/G single nucleotide polymorphisms and myasthenia gravis patients in Fujian province.Method:The CTLA-4 gene exon 1 region+49A/G polymorphism of myasthenia gravis patients in Fujian area were detected by PCR amplification and restriction fragment length polymorphism method.Result:There were no significant differences between the MG group and the control group in 49A/G locus allele and genotype,and there was no significant connection between MG and CTLA-4 exon 49 single nucleotide polymorphisms in myasthenia gravis patients(P>0.05).The frequency of GG genotype in male patients with MG was significantly higher than female patients(χ2GG=4.41, P=0.04).Conclusion:MG may be not correlated with the haplotype and genotype of CTLA-4 at exon 49 in Fujian area.