CAJ | 학술논문

目的：观察高剂量盐酸氨溴索治疗创伤性湿肺的疗效。方法选取本院168例创伤性湿肺患者，按照随机数表法分为对照组79例(给予常规治疗)和治疗组89例(在常规治疗的基础上给予高剂量盐酸氨溴素100 mg静脉推注，2次/d，持续10 d)。监测两组患者肺部影像学、血气分析等生化指标以及机械通气情况，评估两组患者肺功能恢复程度以及疾病转归。结果肺部影像学结果显示治疗组有效率为85.3%，高于对照组的70.5%，差异有统计学意义(P<0.05)；治疗组治疗10 d后自主呼吸频率、血氧分压(PaO2)值以及血乳酸水平等血气指标均优于对照组，差异均有统计学意义(P<0.05)；治疗组平均机械通气时间短于对照组，差异有统计学意义(P<0.05)。结论高剂量盐酸氨溴索静脉注射可以改善创伤性湿肺引发的肺功能障碍，可以作为创伤性湿肺常规治疗的辅助措施。
목적：관찰고제량염산안추색치료창상성습폐적료효。방법선취본원168례창상성습폐환자，안조수궤수표법분위대조조79례(급여상규치료)화치료조89례(재상규치료적기출상급여고제량염산안추소100 mg정맥추주，2차/d，지속10 d)。감측량조환자폐부영상학、혈기분석등생화지표이급궤계통기정황，평고량조환자폐공능회복정도이급질병전귀。결과폐부영상학결과현시치료조유효솔위85.3%，고우대조조적70.5%，차이유통계학의의(P<0.05)；치료조치료10 d후자주호흡빈솔、혈양분압(PaO2)치이급혈유산수평등혈기지표균우우대조조，차이균유통계학의의(P<0.05)；치료조평균궤계통기시간단우대조조，차이유통계학의의(P<0.05)。결론고제량염산안추색정맥주사가이개선창상성습폐인발적폐공능장애，가이작위창상성습폐상규치료적보조조시。
Objective To observe the protective role of high-dose ambroxol hydrochlorideon in the treat-ment of traumatic wet lung. Methods One hundred and sixty-eight patients with traumatic wet lung were randomly divided into the treatment group (n=89) and the control group (n=79). The control group received normal treatment, while the treatment group received additional high-dose ambroxol hydrochloride injection 100 mg twice per day for 10 days. X-ray, blood gas analysis and mechanical ventilation were detected during the procedure, which showed the functional recovery of lung and the prognosis of disease. Results The effective rate of the treatment group was 85.3%, significantly higher than 70.5%of the control group (P<0.05). Ten days after treatment, the respiration frequen-cy, PaO2 and the concentration of blood lactate in the treatment group were all significantly better than those in the con-trol group (P<0.05). The mean time of mechanical ventilation of treatment group was shorter than the control group (t=5.965, P<0.05). Conclusion High-dose ambroxol hydrochloride injection has protective effects on curing traumat-ic wet lung, which can be applied as an assisted treatment for normal treatmen.