海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
4期
481-483
,共3页
鸟氨酸脱羧酶%CD105蛋白%外阴鳞癌%外阴上皮内瘤变
鳥氨痠脫羧酶%CD105蛋白%外陰鱗癌%外陰上皮內瘤變
조안산탈최매%CD105단백%외음린암%외음상피내류변
Ornithine decarboxylase (ODC)%Cluster of differentiation 105 (CD105)%Vulvar squamous carcino-ma%Vulvar intraepithelial neoplasia
目的：探讨鸟氨酸脱梭酶(Ornithine decarboxylase，ODC)和CD105蛋白(Cluster of differentiation 105，CD105)在外阴癌变中的作用。方法选取30例外阴鳞癌、30例外阴上皮内瘤变和30例外阴正常表皮，采用免疫组化的方法进行研究。分析ODC和CD105表达与外阴鳞癌的临床病理特征。结果 ODC和CD105在正常外阴组织中的阳性率明显低于外阴上皮内瘤变组织和外阴鳞癌组织，而于外阴上皮内瘤变组织中的阳性率明显低于外阴鳞癌组织，差异均有显著统计学意义(P<0.01)，ODC与细胞分化程度密切相关(P<0.05)，CD105与临床分期和淋巴转移密切相关(P<0.05)。结论 ODC和CD105在外阴鳞癌发生和发展中具有重要的意义。
目的：探討鳥氨痠脫梭酶(Ornithine decarboxylase，ODC)和CD105蛋白(Cluster of differentiation 105，CD105)在外陰癌變中的作用。方法選取30例外陰鱗癌、30例外陰上皮內瘤變和30例外陰正常錶皮，採用免疫組化的方法進行研究。分析ODC和CD105錶達與外陰鱗癌的臨床病理特徵。結果 ODC和CD105在正常外陰組織中的暘性率明顯低于外陰上皮內瘤變組織和外陰鱗癌組織，而于外陰上皮內瘤變組織中的暘性率明顯低于外陰鱗癌組織，差異均有顯著統計學意義(P<0.01)，ODC與細胞分化程度密切相關(P<0.05)，CD105與臨床分期和淋巴轉移密切相關(P<0.05)。結論 ODC和CD105在外陰鱗癌髮生和髮展中具有重要的意義。
목적：탐토조안산탈사매(Ornithine decarboxylase，ODC)화CD105단백(Cluster of differentiation 105，CD105)재외음암변중적작용。방법선취30예외음린암、30예외음상피내류변화30예외음정상표피，채용면역조화적방법진행연구。분석ODC화CD105표체여외음린암적림상병리특정。결과 ODC화CD105재정상외음조직중적양성솔명현저우외음상피내류변조직화외음린암조직，이우외음상피내류변조직중적양성솔명현저우외음린암조직，차이균유현저통계학의의(P<0.01)，ODC여세포분화정도밀절상관(P<0.05)，CD105여림상분기화림파전이밀절상관(P<0.05)。결론 ODC화CD105재외음린암발생화발전중구유중요적의의。
Objective To discuss the role of ornithine decarboxylase (ODC) and cluster of differentiation 105 (CD105) in vulvar tumor. Methods Thirty cases of malignant vulvar tumors, 30 cases of vulvar intraepithelial neo-plasia, and 30 cases of normal vulvar tissue were studied by immunohistochemistry. ODC and CD105 expression and clinical pathological features of vulvar squamous carcinoma were further analyzed. Results The positive expression rate of ODC and CD105 in normal vulvar tissues was significantly lower than that in the genital intraepithelial neoplasia and squamous cell carcinoma of the vulva, and the positive rate in vulvar intraepithelial neoplasia was significantly lower than that in vulvar squamous cell carcinoma tissue, with statistically significant difference (P<0.01). ODC was closely related to the degree of cell differentiation (P<0.05), and CD105 was closely related to clinical stage and lymph node metastasis (P<0.05). Conclusion ODC and CD105 had vital significance in the development of vulvar squamous carcinoma (HCC).
