CAJ | 학술논문

目的：探讨长脉冲1064nm Nd：YAG激光联合胶原修复贴治疗中度痤疮的疗效及安全性。方法：128例中度痤疮患者，随机分为激光组44例、激光联合胶原修复贴组（简称联合组）44例和药物组40例，激光组使用长脉冲Nd：YAG激光，设定治疗参数（波长1064 nm，光斑4 mm，脉宽35 ms，能量密度35~40 J/cm2，频率1.5 Hz）进行激光治疗，共进行4疗程治疗，每次间隔1周，同时配合基础药物治疗；激光联合胶原修复组先进行与激光组相同的激光照射治疗，治疗完毕立即使用胶原修复贴外敷于面部30 min/次，并于每次治疗后3d再次外贴，同时配合基础药物治疗；药物组为基础药物治疗，即口服罗红霉素胶囊，外用2%莫匹罗星软膏；治疗4周后评价疗效。结果：治疗4周后激光组有效率为90.1%，联合组有效率为93.1%，与药物组相比差异均有统计学意义（P<0.05）。治疗结束2月后随访，联合组未发生炎症后色素沉着与激光组、药物组比较差异均有统计学意义（P<0.05）。结论：长脉冲1064nm Nd：YAG激光联合胶原修复贴是治疗中度痤疮的有效方法，近期疗效明确，副作用小。
목적：탐토장맥충1064nm Nd：YAG격광연합효원수복첩치료중도좌창적료효급안전성。방법：128례중도좌창환자，수궤분위격광조44례、격광연합효원수복첩조（간칭연합조）44례화약물조40례，격광조사용장맥충Nd：YAG격광，설정치료삼수（파장1064 nm，광반4 mm，맥관35 ms，능량밀도35~40 J/cm2，빈솔1.5 Hz）진행격광치료，공진행4료정치료，매차간격1주，동시배합기출약물치료；격광연합효원수복조선진행여격광조상동적격광조사치료，치료완필립즉사용효원수복첩외부우면부30 min/차，병우매차치료후3d재차외첩，동시배합기출약물치료；약물조위기출약물치료，즉구복라홍매소효낭，외용2%막필라성연고；치료4주후평개료효。결과：치료4주후격광조유효솔위90.1%，연합조유효솔위93.1%，여약물조상비차이균유통계학의의（P<0.05）。치료결속2월후수방，연합조미발생염증후색소침착여격광조、약물조비교차이균유통계학의의（P<0.05）。결론：장맥충1064nm Nd：YAG격광연합효원수복첩시치료중도좌창적유효방법，근기료효명학，부작용소。
Objective:To investigate the efficacy and safety of combining 1064nm Nd:YAG laser and collagen dressing for the treatment of moderate acne.Method:The 128 moderate acne cases were divided into laser treatment group of 44cases,laser and collagen dressing group of 44cases and control group of 40cases.The patients were treated for 4 sessions in a week interval and were treated with roxithromycin meanwhile.The laser was set to 35~40 J/cm2,with a 35 ms pulse duration,a repetition rate of 1.5 Hz and a spot size of 4 mm in diameter.In laser and collagen dressing group, after the laser treatment,each patient was given a collagen dressing for 30 min,and another collagen dressing 3 days later. Cases in control group were treated with roxithromycin.The efficacy was evaluated 4 weeks after the treatment.Result:The markedly effective rate in laser group and laser jion collagen dressing group 4 weeks after the treatment was 90.1%and 93.1%respectively,significantly higher than that of the control group,the differences were statistically significant ( P<0.05).A follow-up of 2 months revealed the combination of 1064 nm Nd:YAG laser and collagen dressing improved the postinflammatory hyperpigmentation significantly,the differences were statistically significant(P<0.05). Conclusion:The combination of 1064 nm Nd:YAG laser and collagen dressing could be a useful treatment alternative for patients with moderate acne.