中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
4期
11-13
,共3页
胰岛素泵%强化治疗%初发2型糖尿病
胰島素泵%彊化治療%初髮2型糖尿病
이도소빙%강화치료%초발2형당뇨병
Insulin pump%Intensive therapy%Incipient Type 2 Diabetes
目的：探讨胰岛素泵与胰岛素皮下注射强化疗法治疗初发2型糖尿病的临床疗效。方法：选取120例2型糖尿病初发患者并按随机数字表法分为两组，A组（胰岛素泵强化治疗）58例和B组（胰岛素皮下注射强化治疗）62例，观察两组治疗前、治疗2周及治疗6个月后空腹血糖（FBG）、餐后2 h血糖（PBG2 h）、糖化血红蛋白（HbA1c）、空腹C-肽（C-P）及餐后2 h C-P（C-P 2 h）及血糖达标时间、胰岛素用量、低血糖发生次数。结果：两组患者治疗后，空腹血糖、餐后2 h血糖水平、糖化血红蛋白（HbA1c）均下降（P<0.05），空腹血清C-P、C-P 2 h均升高（P<0.05）；治疗6个月A组空腹血清C-P、C-P 2 h升高较B组明显，比较差异有统计学意义（P<0.05）；治疗前后A组与B组空腹血糖、餐后2 h血糖水平比较差异均无统计学意义。A组胰岛素用量、血糖达标时间、低血糖次数明显低于B组，比较差异有统计学意义（P<0.05）。结论：胰岛素泵强化治疗初发2型糖尿病临床疗效与皮下注射强化治疗疗效相当，但前者可缩短血糖达标时间，减少胰岛素用量，降低低血糖发生率，能更快、更平稳地控制血糖，是治疗初发2型糖尿病的首选方案。
目的：探討胰島素泵與胰島素皮下註射彊化療法治療初髮2型糖尿病的臨床療效。方法：選取120例2型糖尿病初髮患者併按隨機數字錶法分為兩組，A組（胰島素泵彊化治療）58例和B組（胰島素皮下註射彊化治療）62例，觀察兩組治療前、治療2週及治療6箇月後空腹血糖（FBG）、餐後2 h血糖（PBG2 h）、糖化血紅蛋白（HbA1c）、空腹C-肽（C-P）及餐後2 h C-P（C-P 2 h）及血糖達標時間、胰島素用量、低血糖髮生次數。結果：兩組患者治療後，空腹血糖、餐後2 h血糖水平、糖化血紅蛋白（HbA1c）均下降（P<0.05），空腹血清C-P、C-P 2 h均升高（P<0.05）；治療6箇月A組空腹血清C-P、C-P 2 h升高較B組明顯，比較差異有統計學意義（P<0.05）；治療前後A組與B組空腹血糖、餐後2 h血糖水平比較差異均無統計學意義。A組胰島素用量、血糖達標時間、低血糖次數明顯低于B組，比較差異有統計學意義（P<0.05）。結論：胰島素泵彊化治療初髮2型糖尿病臨床療效與皮下註射彊化治療療效相噹，但前者可縮短血糖達標時間，減少胰島素用量，降低低血糖髮生率，能更快、更平穩地控製血糖，是治療初髮2型糖尿病的首選方案。
목적：탐토이도소빙여이도소피하주사강화요법치료초발2형당뇨병적림상료효。방법：선취120례2형당뇨병초발환자병안수궤수자표법분위량조，A조（이도소빙강화치료）58례화B조（이도소피하주사강화치료）62례，관찰량조치료전、치료2주급치료6개월후공복혈당（FBG）、찬후2 h혈당（PBG2 h）、당화혈홍단백（HbA1c）、공복C-태（C-P）급찬후2 h C-P（C-P 2 h）급혈당체표시간、이도소용량、저혈당발생차수。결과：량조환자치료후，공복혈당、찬후2 h혈당수평、당화혈홍단백（HbA1c）균하강（P<0.05），공복혈청C-P、C-P 2 h균승고（P<0.05）；치료6개월A조공복혈청C-P、C-P 2 h승고교B조명현，비교차이유통계학의의（P<0.05）；치료전후A조여B조공복혈당、찬후2 h혈당수평비교차이균무통계학의의。A조이도소용량、혈당체표시간、저혈당차수명현저우B조，비교차이유통계학의의（P<0.05）。결론：이도소빙강화치료초발2형당뇨병림상료효여피하주사강화치료료효상당，단전자가축단혈당체표시간，감소이도소용량，강저저혈당발생솔，능경쾌、경평은지공제혈당，시치료초발2형당뇨병적수선방안。
Objective:To study the clinical effect of the intensive therapy with insulin pump and subcutaneous insulin infusion in treating incipient type 2 diabetes.Method:120 patients with incipient type 2 diabetes were randomly divided into two groups,58 in Group A(insulin pump intensive therapy)and 62 in Group B(subcutaneous insulin infusion intensive therapy).Changes of fasting blood glucose(FBG),BG 2 hours after meal(PBG2 h),glycosylated emoglobin(HBA1C),fasting C-peptide(C-P)and C-P 2hrs after meal were observed,and the time of BG to target, insulin dosage,and the frequency of hypoglycaemia before and after treatment,2 weeks and 6 months after treatment were also observed.Result:After treatment,FBG,BG 2 hrs after meal and HBA1C were lower for the patients in both groups (P<0.05),while fasting C-P、C-P 2 h were elevated(P<0.05).After 6 months’ treatment,the increase in fasting C-P and C-P 2 h in Group A was significantly elevated than those in Group B(P<0.05).The differences of FBG and BG 2 h had no statistical significance.Insulin dosage,time of BG to target and the frequency of hypoglycaemia were obviously lower than those of Group B(P<0.05).Conclusion:The clinical effect of insulin pump therapy to incipient type 2 diabetes is almost equal to that of subcutaneous insulin infusion,whereas the former could shorten the time of blood glucose to target, reduce the dosage of insulin and the incidence of hypoglycemia with a quicker and smooth blood glucose control.The insulin pump therapy should be the first choice to the incipient type 2 diabetes patients.
