中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
4期
112-115
,共4页
多粘菌素B%美罗培南%泛耐药%铜绿假单胞菌%有效性
多粘菌素B%美囉培南%汎耐藥%銅綠假單胞菌%有效性
다점균소B%미라배남%범내약%동록가단포균%유효성
Polymyxin B%Meropenem%Pan-resistant%Pseudomonas aeruginosa%Effectiveness
目的：对多粘菌素B联合美罗培南用于泛耐药铜绿假单胞菌体外抗菌活性的有效性进行分析。方法：用微量肉汤稀释法、棋盘法等对多粘菌素B与美罗培南单独用药及两者联合用药后进行测定，临床分离出的60株泛耐药铜绿假单胞菌的最小抑菌浓度（MIC），并计算出部分抑菌浓度指数（FIC），同时依据FIC指数来判定出联合效应的类型，判定其有效性。结果：多粘菌素B和美罗培南在联用后，药物对泛耐药铜绿假单胞菌的MIC值都明显降低，FIC指数处于0~0.5的占全部菌株数量的60%；FIC指数处于0.5~1.0的占全部菌株数量的30%；FIC指数处于1.0~2.0的占全部菌株数量的10%；无FIC指数大于2的菌株。结论：多粘菌素B和美罗培南两药联用后，主要以协同作用及相加作用为主，测定分离的60株泛耐药铜绿假单胞菌具备抗菌作用，但是并不具备拮抗作用。多粘菌素B联合美罗培南用于疾病临床治疗，可有效提高临床治疗效果，且安全性较高，值得临床推广。
目的：對多粘菌素B聯閤美囉培南用于汎耐藥銅綠假單胞菌體外抗菌活性的有效性進行分析。方法：用微量肉湯稀釋法、棋盤法等對多粘菌素B與美囉培南單獨用藥及兩者聯閤用藥後進行測定，臨床分離齣的60株汎耐藥銅綠假單胞菌的最小抑菌濃度（MIC），併計算齣部分抑菌濃度指數（FIC），同時依據FIC指數來判定齣聯閤效應的類型，判定其有效性。結果：多粘菌素B和美囉培南在聯用後，藥物對汎耐藥銅綠假單胞菌的MIC值都明顯降低，FIC指數處于0~0.5的佔全部菌株數量的60%；FIC指數處于0.5~1.0的佔全部菌株數量的30%；FIC指數處于1.0~2.0的佔全部菌株數量的10%；無FIC指數大于2的菌株。結論：多粘菌素B和美囉培南兩藥聯用後，主要以協同作用及相加作用為主，測定分離的60株汎耐藥銅綠假單胞菌具備抗菌作用，但是併不具備拮抗作用。多粘菌素B聯閤美囉培南用于疾病臨床治療，可有效提高臨床治療效果，且安全性較高，值得臨床推廣。
목적：대다점균소B연합미라배남용우범내약동록가단포균체외항균활성적유효성진행분석。방법：용미량육탕희석법、기반법등대다점균소B여미라배남단독용약급량자연합용약후진행측정，림상분리출적60주범내약동록가단포균적최소억균농도（MIC），병계산출부분억균농도지수（FIC），동시의거FIC지수래판정출연합효응적류형，판정기유효성。결과：다점균소B화미라배남재련용후，약물대범내약동록가단포균적MIC치도명현강저，FIC지수처우0~0.5적점전부균주수량적60%；FIC지수처우0.5~1.0적점전부균주수량적30%；FIC지수처우1.0~2.0적점전부균주수량적10%；무FIC지수대우2적균주。결론：다점균소B화미라배남량약련용후，주요이협동작용급상가작용위주，측정분리적60주범내약동록가단포균구비항균작용，단시병불구비길항작용。다점균소B연합미라배남용우질병림상치료，가유효제고림상치료효과，차안전성교고，치득림상추엄。
Objective:To analyze the effectiveness of polymyxin B in combination with meropenem for pan-drug resistant pseudomonas aeruginosa vitro antimicrobial activity.Method:After polymyxin B and meropenem were used alone and used together,the minimum inhibitory concentration of the 60 strains of pan-drug resistant pseudomonas aeruginosa which were clinically separated was tested through broth dilution method,checkerboard method and so on.And also the fractional inhibitory concentration index(FIC)was calculated.At the same time,the type and the effectiveness of the joint effect was determined according to the fractional inhibitory concentration index.Result:After the joint use of Polymyxin B and Meropenem,the fractional inhibitory concentration index of the medicine on the pan-drug resistant pseudomonas aeruginosa significantly reduced.Among these 60 strains of pan-drug resistant pseudomonas aeruginosa,those whose FIC at 0-0.5 accounted for 60%,at 0.5-1.0 accounted for 30%,at 1.0-2.0 accounted for 10%,but none of them whose FIC was over 2.Conclusion:When Polymyxin B and Meropenem are used together,they are mainly dominated by synergistic and additive effect.The 60 strains of pan-drug resistant pseudomonas aeruginosa which are separated have antibacterial effect.However,they do not have antagonistic effects.
