CAJ | 학술논문

同轴静电纺丝法制备的聚乳酸-乙醇酸（PLGA）纳米纤维具有良好的生物相容性和生物可降解性，加之其高孔隙率和高透氧率，使其能成为优良的药物载体。本文初步摸索了 PLGA 的同轴静电纺丝的工艺条件，并通过同轴静电纺丝法制备了 PLGA载氟比洛芬酯（FA）的纳米纤维膜，应用扫描电子显微镜、红外光谱分析观察纤维的表观形貌并确定其微观结构。重点探究了不同溶剂配比的混合溶剂对载药纤维膜药物释放性能影响。研究结果表明在U+为+15.00kV，U?为?2.50kV，接受距离为15cm，壳层推进速度为0.4mm/min，芯层推进速度为0.1mm/min进行静电纺丝时，所制备的PLGA(壳)/PVP+FA(核)复合载药纤维膜壳核结构良好，且成功载了约0.5%的FA。当改变壳层混合溶剂（DCM和DMF）和芯层混合溶剂（无水乙醇和DMF）体积比时，纤维直径会随着DMF的减少而增大。
동축정전방사법제비적취유산-을순산（PLGA）납미섬유구유량호적생물상용성화생물가강해성，가지기고공극솔화고투양솔，사기능성위우량적약물재체。본문초보모색료 PLGA 적동축정전방사적공예조건，병통과동축정전방사법제비료 PLGA재불비락분지（FA）적납미섬유막，응용소묘전자현미경、홍외광보분석관찰섬유적표관형모병학정기미관결구。중점탐구료불동용제배비적혼합용제대재약섬유막약물석방성능영향。연구결과표명재U+위+15.00kV，U?위?2.50kV，접수거리위15cm，각층추진속도위0.4mm/min，심층추진속도위0.1mm/min진행정전방사시，소제비적PLGA(각)/PVP+FA(핵)복합재약섬유막각핵결구량호，차성공재료약0.5%적FA。당개변각층혼합용제（DCM화DMF）화심층혼합용제（무수을순화DMF）체적비시，섬유직경회수착DMF적감소이증대。
PLGA [poly(1actic-co-glycolic acid)] coaxial electrospinning nanofiber is a biodegradable material with good biocompatibility. In addition,its high porosity and high oxygen permeability would also favor PLGA to become a good pharmaceutical carrier. The technological conditions of electrospinning were studied and flurbiprofen axetil (FA)-loaded PLGA nanofibers were prepared by coaxial electrospinning. The structure and morphology of the nanofiber were characterized by infrared spectrometer (IR) and scanning electron microscope (SEM),respectively. The influence of solvent’s proportion on nanofibers’ drug release properties was investigated. When positive voltage,negative voltage,receive distance,advancing speed of the shell as well as the core is+15.00kV,?2.50kV,15cm,0.4mm/min,0.1mm/min,respectively. The prepared PLGA/PVP FA-loaded electrospun fibers had a good core-shell structure,and carried successfully about 0.5%FA. Besides,when volume ratio of the shell’s mixed solvent (DCM and DMF) and the core’s mixed solvent (anhydrous ethanol and DMF) changed,fiber diameter would increase with the decrease of DMF.