医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
3期
296-297,300
,共3页
唐广心%叶发忠%刘晓军%彭敬
唐廣心%葉髮忠%劉曉軍%彭敬
당엄심%협발충%류효군%팽경
低/无应答%60μg%乙肝疫苗
低/無應答%60μg%乙肝疫苗
저/무응답%60μg%을간역묘
Low/non-response%Hepaitis B vaccine(60μg)
目的：探讨低／无应答的成年人接种60μg乙肝疫苗后的抗体产生状况及其影响因素。方法：在深圳市某医院既往接受过乙肝疫苗0、1、6程序接种而未产生保护性抗体的职工中，接种深圳康泰生物制品股份有限公司生产的60μg重组乙型肝炎（酿酒酵母）疫苗，1年后采集接种者血清，采用化学发光免疫分析法（CLIA法）检测抗‐HBs水平。同时对接种者进行问卷调查，采用非条件 Logistic回归分析，以了解影响乙肝疫苗免疫应答的因素。结果：本次调查共发出问卷121份，收回有效问卷111份，有效回收率为91．74％。接种后，乙肝抗体阳转率达100．0％，乙肝保护性抗体阳转率达91．89％。非条件 Logistic回归分析后显示，经常接触乙肝患者、肥胖、熬夜、子女接种乙肝疫苗后无抗体、父亲接种乙肝疫苗后无抗体、母亲接种乙肝疫苗后无抗体、饮酒等因素对接种乙肝疫苗无（弱）应答率的影响均无统计学意义。结论：低／无应答者接种一针高剂量60μg乙肝疫苗，可获得较好抗体应答。尚未发现影响接种乙肝疫苗无（弱）应答率的因素。
目的：探討低／無應答的成年人接種60μg乙肝疫苗後的抗體產生狀況及其影響因素。方法：在深圳市某醫院既往接受過乙肝疫苗0、1、6程序接種而未產生保護性抗體的職工中，接種深圳康泰生物製品股份有限公司生產的60μg重組乙型肝炎（釀酒酵母）疫苗，1年後採集接種者血清，採用化學髮光免疫分析法（CLIA法）檢測抗‐HBs水平。同時對接種者進行問捲調查，採用非條件 Logistic迴歸分析，以瞭解影響乙肝疫苗免疫應答的因素。結果：本次調查共髮齣問捲121份，收迴有效問捲111份，有效迴收率為91．74％。接種後，乙肝抗體暘轉率達100．0％，乙肝保護性抗體暘轉率達91．89％。非條件 Logistic迴歸分析後顯示，經常接觸乙肝患者、肥胖、熬夜、子女接種乙肝疫苗後無抗體、父親接種乙肝疫苗後無抗體、母親接種乙肝疫苗後無抗體、飲酒等因素對接種乙肝疫苗無（弱）應答率的影響均無統計學意義。結論：低／無應答者接種一針高劑量60μg乙肝疫苗，可穫得較好抗體應答。尚未髮現影響接種乙肝疫苗無（弱）應答率的因素。
목적：탐토저／무응답적성년인접충60μg을간역묘후적항체산생상황급기영향인소。방법：재심수시모의원기왕접수과을간역묘0、1、6정서접충이미산생보호성항체적직공중，접충심수강태생물제품고빈유한공사생산적60μg중조을형간염（양주효모）역묘，1년후채집접충자혈청，채용화학발광면역분석법（CLIA법）검측항‐HBs수평。동시대접충자진행문권조사，채용비조건 Logistic회귀분석，이료해영향을간역묘면역응답적인소。결과：본차조사공발출문권121빈，수회유효문권111빈，유효회수솔위91．74％。접충후，을간항체양전솔체100．0％，을간보호성항체양전솔체91．89％。비조건 Logistic회귀분석후현시，경상접촉을간환자、비반、오야、자녀접충을간역묘후무항체、부친접충을간역묘후무항체、모친접충을간역묘후무항체、음주등인소대접충을간역묘무（약）응답솔적영향균무통계학의의。결론：저／무응답자접충일침고제량60μg을간역묘，가획득교호항체응답。상미발현영향접충을간역묘무（약）응답솔적인소。
Objective :To evaluate the effectiveness of hepatitis B vaccine (60μg) in the low‐responding adult subjects and the influence factors of non‐response to hepatitis B vaccine .Methods:Staffs in a hospital with a history of immuni‐zation with hepatitis B vaccine but negative for hepatitis B markers were randomly selected and were administered a 60μg dose of a vaccine .The level of serum anti‐HBs was determined 12 months after injection .Non‐conditional logistic regression was adopted to analyze the influence factors of non‐response to hepatitis B vaccine .Results:A questionnaire survey was conducted among the 121 staffs .Within the 121 questionnaires ,there were 111 effective responses .111 subjects were selected .After administration ,the anti‐HBs sero‐conversion rate was 100 .0% and the seroprotection rate was 91 .89% .Logistic regression analysis suggested that contacting with hepatitis B patient ,obesity ,no immune response after hepatitis B vaccination ,drink were not associated with non‐response to hepatitis B vaccine immune .Con‐clusion:The immunogenicity of a 60μg hepatitis B vaccine was good in adults with a low /non‐response rate .The influ‐ence factors of non‐response to hepatitis B vaccine were not found .
