CAJ | 학술논문

目的：探讨乳腺浸润性导管癌中雌激素调节蛋白（PS2）的表达及其与雌激素受体（ER）、孕激素受体（PR）的关系。方法收集新疆医科大学附属肿瘤医院2008－2009年经病理确诊并行外科手术治疗的70例乳腺浸润性导管癌组织石蜡标本，采用免疫组化法检测 PS2、ER、PR 表达，分析 PS2与 ER、PR 表达及临床病理因素的相关关系。结果PS2、ER、PR 阳性表达率分别为37．14％（26／70）、40．00％（28／70）、42．86％（30／70）。PS2在ER 阳性和阴性病例中的阳性表达率分别为60．71％（17／28）和21．43％（9／42），两者差异有统计学意义（P ＜0．05）。PS2在 PR 阳性和阴性病例中的阳性表达率分别为66．67％（20／30）和15．00％（6／40），两者差异有统计学意义（P ＜0．05）。患者年龄、月经状态与 PS2蛋白表达无明显关系（P ＞0．05），PS2表达与 ER 呈正相关（γs ＝0．35，P ＝0．014），PS2表达与 PR 呈正相关（γs ＝0．475，P ＝0．000），PS2表达与患者组织分级及淋巴结转移有关（P ＜0．05）。结论PS2表达与 ER、PR 及淋巴结转移状况与组织分级临床因素有关。ER、PR、PS2综合检测对判定乳腺内分泌治疗效果及预后具有重要意义。
목적：탐토유선침윤성도관암중자격소조절단백（PS2）적표체급기여자격소수체（ER）、잉격소수체（PR）적관계。방법수집신강의과대학부속종류의원2008－2009년경병리학진병행외과수술치료적70례유선침윤성도관암조직석사표본，채용면역조화법검측 PS2、ER、PR 표체，분석 PS2여 ER、PR 표체급림상병리인소적상관관계。결과PS2、ER、PR 양성표체솔분별위37．14％（26／70）、40．00％（28／70）、42．86％（30／70）。PS2재ER 양성화음성병례중적양성표체솔분별위60．71％（17／28）화21．43％（9／42），량자차이유통계학의의（P ＜0．05）。PS2재 PR 양성화음성병례중적양성표체솔분별위66．67％（20／30）화15．00％（6／40），량자차이유통계학의의（P ＜0．05）。환자년령、월경상태여 PS2단백표체무명현관계（P ＞0．05），PS2표체여 ER 정정상관（γs ＝0．35，P ＝0．014），PS2표체여 PR 정정상관（γs ＝0．475，P ＝0．000），PS2표체여환자조직분급급림파결전이유관（P ＜0．05）。결론PS2표체여 ER、PR 급림파결전이상황여조직분급림상인소유관。ER、PR、PS2종합검측대판정유선내분비치료효과급예후구유중요의의。
Objective To study the expression of PS2 and the clinical correlation between PS2 and ER,PR in patients with breast infiltrating ductal carcinoma.Methods Detect the expression of PS2,ER and PR in 70 cases of samples in patients with breast infiltrating ductal carcinoma by using immunohistochemical method.The clinical relevance of the PS2 with ER,PR and clinical factors were analyzed.Results The positive rates of PS2,ER,PR were 37.14%(26/70),40.0%(28/70),42.86%(30/70)respectively.The positive expression rate of PS2 was 60.71%(17/28)for the ER positive group and 21.43%(9/42)for the ER negative group.There were significant differences (P <0.05).The positive rate of PS2 protein in PR positive group and negative group were 66.67%(20/30)and 15.00%(6/40)respectively.The menstrual status and age of patients had no significant effects on the PS2 protein expression (P >0.05).The expres-sion of PS2 protein could be affected by the clinical stages and lymphatic metastasis (P <0.05).Conclusion The expression of PS2 in breast infiltrating ductal carcinoma was significantly correlated with ER,PR and the pathological factors such as clinical stages and lymph node metastasis status.The comprehensive test of ER,PR,PS2 had great significance in determining the effect of endocrine treatment and prognosis of breast cancer.