CAJ | 학술논문

目的：探讨补肾安胎中药滋肾育胎丸在体外受精-胚胎移植各环节起效所需的用药持续时间。方法选取拟行体外受精-胚胎移植且符合中医辨证肾虚型不孕症患者150例，随机分为对照组、治疗1组和治疗2组，每组各50例，对照组行 GnRH-a 长方案降调，Gn 促排卵。在对照组用药基础上，治疗1组促排周期第3天开始使用滋肾育胎丸，治疗2组促排卵前1个周期第3天开始使用至胚胎移植后2 w。结果3组 Gn 用量及用药天数比较差异无统计学意义（P ＞0．05），2个治疗组 HCG 日子宫内膜均厚于对照组，差异有统计学意义（P ＜0．05），3组取卵数、卵裂数比较差异无统计学意义（P ＞0．05），治疗2组 2PN 受精数、优质胚胎数多于对照组和治疗1组，差异有统计学意义（P ＜0．05），3组总妊娠率比较差异无统计学意义，治疗2组临床妊娠率高，生化妊娠、胎停率、流产率低于治疗1组与对照组，差异有统计学意义（P ＜0．05）。结论促排卵周期配合滋肾育胎丸能够增加子宫内膜厚度，促排卵前1个周期配合持续使用滋肾育胎丸能够改善卵细胞质量，降低流产率，提高临床受孕率。
목적：탐토보신안태중약자신육태환재체외수정-배태이식각배절기효소수적용약지속시간。방법선취의행체외수정-배태이식차부합중의변증신허형불잉증환자150례，수궤분위대조조、치료1조화치료2조，매조각50례，대조조행 GnRH-a 장방안강조，Gn 촉배란。재대조조용약기출상，치료1조촉배주기제3천개시사용자신육태환，치료2조촉배란전1개주기제3천개시사용지배태이식후2 w。결과3조 Gn 용량급용약천수비교차이무통계학의의（P ＞0．05），2개치료조 HCG 일자궁내막균후우대조조，차이유통계학의의（P ＜0．05），3조취란수、란렬수비교차이무통계학의의（P ＞0．05），치료2조 2PN 수정수、우질배태수다우대조조화치료1조，차이유통계학의의（P ＜0．05），3조총임신솔비교차이무통계학의의，치료2조림상임신솔고，생화임신、태정솔、유산솔저우치료1조여대조조，차이유통계학의의（P ＜0．05）。결론촉배란주기배합자신육태환능구증가자궁내막후도，촉배란전1개주기배합지속사용자신육태환능구개선란세포질량，강저유산솔，제고림상수잉솔。
Objective To explore the time duration that Zishen Yutai Pill required to play effect in various stages of IVF.Methods 150 infertile patients with intended in vitro fertilization-embryo transfer and com-pliance with TCM for Kidney type were selected and randomly divided into Control Group,Treatment Group 1 and Treatment Group 2,with 50 cases in each group.GnRH-a and Gn ovulation were used in Con-trol Group.Based on the treatment in Control Group,Treatment Group 1 started to take Zishen Yutai Pill on the third day in the vulation cycle;Treatment Group 2 started to take Zishen Yutai Pill on the third day before the ovulation cycle until 2 weeks after the embryo transfer.Results There was no statistical signifi-cance (P >0.05)in Gn medication dosage and number of days among the three groups.HCG day endome-trial thickness in two treatment groups was thicker than that in the control group,with significant differ-ence statistically (P <0.05).There was no statistical significance (P >0.05)in the number of harvested o-ocytes and cleavage in three groups.2PN fertilization number of high-quality embryos in treatment group 2 was more than that in the control group and treatment group 1,with significant difference statistically (P<0.05).The total pregnancy rate in the three groups was not statistically significant (P >0.05).Treat-ment group 2 had higher clinical pregnancy rate,lower biochemical pregnancy rate,fetal stop rate and a-bortion rate than those in the treatment group 1 and the control group,with significant difference (P <0. 05).Conclusion The intake of Zishen Yutai Pill in ovulation cycle helped to increase the thickness of en-dometrial.The sustainable use of Zishen Yutai Pill Before ovulation cycle proved to improve the quality of oocyte,reduce the abortion rate and increase the clinical pregnancy rate.