新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2015年
3期
299-301
,共3页
色素上皮衍生因子%增殖性糖尿病视网膜病变%总抗氧化能力
色素上皮衍生因子%增殖性糖尿病視網膜病變%總抗氧化能力
색소상피연생인자%증식성당뇨병시망막병변%총항양화능력
pigment epithelium-derived factor (PEDF)%proliferative diabetic retinopathy (PDR)%total an-ti-oxidant capacity (TAOC)
目的：探讨增殖性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）患者玻璃体液中色素上皮衍生因子（pigment epithelium-derived factor，PEDF）与总抗氧化能力（total anti-oxidant capacity ，TAOC）的关系。方法选择行玻璃体切割术的增殖性糖尿病视网膜病变患者20例（20眼），其中 PDR 合并玻璃体出血组12眼，PDR 无玻璃体出血组8眼。非糖尿病患者18例（18眼）作为对照组。采用 ELISA 方法测定玻璃体液中 PEDF和 TAOC 的水平，并行统计学分析。结果与对照组比较，PDR 患者玻璃体液中的 TAOC 明显降低（P ＜0．01）。玻璃体液中 PEDF 水平与 TAOC 呈正相关（r ＝0．35，P ＜0．05），和对照组呈正相关（r ＝0．39，P ＜0．05）。无玻璃体出血组 PDR 患者玻璃体液中 PEDF 水平与对照组和合并玻璃体出血组比较明显降低（P ＜0．05）。结论玻璃体液中 PEDF 水平与 TAOC 密切相关。PEDF 可作为眼内源性抗氧化物并对 PDR 起到保护作用。
目的：探討增殖性糖尿病視網膜病變（proliferative diabetic retinopathy，PDR）患者玻璃體液中色素上皮衍生因子（pigment epithelium-derived factor，PEDF）與總抗氧化能力（total anti-oxidant capacity ，TAOC）的關繫。方法選擇行玻璃體切割術的增殖性糖尿病視網膜病變患者20例（20眼），其中 PDR 閤併玻璃體齣血組12眼，PDR 無玻璃體齣血組8眼。非糖尿病患者18例（18眼）作為對照組。採用 ELISA 方法測定玻璃體液中 PEDF和 TAOC 的水平，併行統計學分析。結果與對照組比較，PDR 患者玻璃體液中的 TAOC 明顯降低（P ＜0．01）。玻璃體液中 PEDF 水平與 TAOC 呈正相關（r ＝0．35，P ＜0．05），和對照組呈正相關（r ＝0．39，P ＜0．05）。無玻璃體齣血組 PDR 患者玻璃體液中 PEDF 水平與對照組和閤併玻璃體齣血組比較明顯降低（P ＜0．05）。結論玻璃體液中 PEDF 水平與 TAOC 密切相關。PEDF 可作為眼內源性抗氧化物併對 PDR 起到保護作用。
목적：탐토증식성당뇨병시망막병변（proliferative diabetic retinopathy，PDR）환자파리체액중색소상피연생인자（pigment epithelium-derived factor，PEDF）여총항양화능력（total anti-oxidant capacity ，TAOC）적관계。방법선택행파리체절할술적증식성당뇨병시망막병변환자20례（20안），기중 PDR 합병파리체출혈조12안，PDR 무파리체출혈조8안。비당뇨병환자18례（18안）작위대조조。채용 ELISA 방법측정파리체액중 PEDF화 TAOC 적수평，병행통계학분석。결과여대조조비교，PDR 환자파리체액중적 TAOC 명현강저（P ＜0．01）。파리체액중 PEDF 수평여 TAOC 정정상관（r ＝0．35，P ＜0．05），화대조조정정상관（r ＝0．39，P ＜0．05）。무파리체출혈조 PDR 환자파리체액중 PEDF 수평여대조조화합병파리체출혈조비교명현강저（P ＜0．05）。결론파리체액중 PEDF 수평여 TAOC 밀절상관。PEDF 가작위안내원성항양화물병대 PDR 기도보호작용。
Objective To observe the expression of pigment epithelium-derived factor (PEDF)and total anti-oxidant capacity (TAOC)in vitreous of patients with proliferative diabetic retinopathy (PDR),and to investigate the relationship between PEDF and TAOC.Methods Vitreous levels of PEDF and TAOC were measured by an ELISA in 20 eyes of 20 diabetic patients with PDR and in 18 eyes of 18 non-diabetic control subjects.Results TAOC in vitreous was significantly lower in diabetic patients with PDR than that in con-trol subjects (0.18±0.04 mmol/L vs 0.26±0.05 mmol/L,P <0.01).PEDF levels were positively correla-ted with TAOC in the vitreous of patients with PDR (r =0.35,P <0.05)and control subjects (r =0.39,P<0.05).Further,PEDF levels in vitreous of PDR patients without vitreous hemorrhage were significantly decreased (P <0.05),compared with those in the control or PDR patients with vitreous hemorrhage (4.1 ±2.4 μg/mL,7.4±3.1 μg/mL,9.1±4.1 μg/mL).Conclusion The study demonstrates that PEDF is as-sociated with TAOC in vitreous,suggesting that PEDF may act as an endogenous anti-oxidant in the eye and could play a protective role against PDR.
