CAJ | 학술논문

目的：探讨文拉法辛治疗抑郁症的临床研究情况。方法：选取2012年12月～2014年1月我院收治的120例抑郁症患者作为研究对象，随机分为观察组60例和对照组60例。对照组给予阿米替林75mg/d治疗，观察组给予文拉法辛75mg/d治疗，治疗8周后比较治疗前后第1周、2周、4周、8周汉密尔顿抑郁量表（HAMD）5项评定疾病严重程度；采用不良反应量表（TESS）评定药物不良反应；采用生活质量综合评定问卷（WHOQOL-100）评定生活质量及临床疗效情况。结果：两组治疗后第1周、2周、4周、8周的抑郁情绪、精神焦虑、睡眠不深的HAMD总分及各因子项目分情况较治疗前明显降低（P＜0.05）。两组认知障碍项目在治疗后第2周、4周、8周评分较治疗前明显降低（P＜0.05），两组体质量治疗后8周评分较治疗前明显降低（P＜0.05），观察组治疗后第2周、4周、8周精神焦虑因子评分低于对照组（P＜0.05），观察组治疗后第2周、4周睡眠不深因子评分低于对照组（P＜0.05），观察组HAMD总分较对照组明显降低（P＜0.05）。观察组痊愈率为16.67%，总有效率为80.00%；对照组痊愈率为15.00%，总有效率为68.33%；观察组总有效率明显高于对照组，差异有统计学意义（P＜0.05）。两组患者治疗8周后WHOQOL-100总分及各因子分均较治疗前升高，且观察组在心理领域、生活领域、社会关系领域、环境领域评分均高于对照组，差异显著具有统计学意义（P＜0.05）。观察组不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。结论：文拉法辛治疗抑郁症起效快，抗焦虑效果明显，安全性高，能更好地提高患者的生活质量。
목적：탐토문랍법신치료억욱증적림상연구정황。방법：선취2012년12월～2014년1월아원수치적120례억욱증환자작위연구대상，수궤분위관찰조60례화대조조60례。대조조급여아미체림75mg/d치료，관찰조급여문랍법신75mg/d치료，치료8주후비교치료전후제1주、2주、4주、8주한밀이돈억욱량표（HAMD）5항평정질병엄중정도；채용불량반응량표（TESS）평정약물불량반응；채용생활질량종합평정문권（WHOQOL-100）평정생활질량급림상료효정황。결과：량조치료후제1주、2주、4주、8주적억욱정서、정신초필、수면불심적HAMD총분급각인자항목분정황교치료전명현강저（P＜0.05）。량조인지장애항목재치료후제2주、4주、8주평분교치료전명현강저（P＜0.05），량조체질량치료후8주평분교치료전명현강저（P＜0.05），관찰조치료후제2주、4주、8주정신초필인자평분저우대조조（P＜0.05），관찰조치료후제2주、4주수면불심인자평분저우대조조（P＜0.05），관찰조HAMD총분교대조조명현강저（P＜0.05）。관찰조전유솔위16.67%，총유효솔위80.00%；대조조전유솔위15.00%，총유효솔위68.33%；관찰조총유효솔명현고우대조조，차이유통계학의의（P＜0.05）。량조환자치료8주후WHOQOL-100총분급각인자분균교치료전승고，차관찰조재심리영역、생활영역、사회관계영역、배경영역평분균고우대조조，차이현저구유통계학의의（P＜0.05）。관찰조불량반응발생솔저우대조조，차이유통계학의의（P＜0.05）。결론：문랍법신치료억욱증기효쾌，항초필효과명현，안전성고，능경호지제고환자적생활질량。
Objective:To explore the clinical research of venlafaxine in the treatment of depression. 120 cases of depression patients methods from 2012 December~2014 year in January in our hospital as the research object, randomly divided into the observation group 60 cases and control group with 60 cases. The control group received amitriptyline in 75mg/d treatment, the observation group was given venlafaxine in the treatment of 75mg/d, after 8 weeks of treatment before and after treatment first, 2,4,8 weeks of Hamilton Depression Scale (HAMD)5 assessment of severity of disease; scale using adverse reaction (TESS)assessment of adverse drug reaction; using a comprehensive assessment of quality of life questionnaire (WHOQOL-100)quality of life and clinical assessment. Results:of the two groups after first,2,4,8 weeks of depression mood, mental anxiety and sleep is not deep HAMD total score and the factor project was significantly lower than those before therapy (P<0.05). Two groups of cognitive impairment after treatment, 4 of 2 projects, 8 week score significantly lower than that before treatment (P<0.05). After 8 weeks, two groups treatment score significantly lower than that before treatment(P<0.05). The patients in the observation group 2,4,8 weeks of anxiety factor score lower than that of the control group (P<0.05). The observation group after treatment 2, 4 weeks of sleep is not deep factor score lower than that of the control group (P<0.05). The observation group HAMD total score significantly lower than the control group (P<0.05). The observation group, the cure rate is 16.67%, the total effective rate was 80%, the cure rate of the control group was 15%, the total effective rate was 68.33%,total effective rate of observation group was significantly higher than the control group,there were significant differences (P<0.05). The patients in the two groups after 8 weeks of treatment, WHOQOL-100 scores and the factor scores were lower than before treatment increased; and observation group in the field of psychological field, field of life, environment, social relationship domain scores were higher than those in the control group, there was significant difference (P<0.05).The adverse reaction in observation group was lower than that of the control group,the difference was statistically significant (P<0.05). Conclusion:Vin Rafa Sin treatment of depression is fast onset, anti anxiety effect is obvious, high safety, can better improve the patients life therapy.