北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
2期
108-108,109
,共2页
躯体形式障碍%度罗西汀联合喹硫平%焦虑%药物不良反应
軀體形式障礙%度囉西汀聯閤喹硫平%焦慮%藥物不良反應
구체형식장애%도라서정연합규류평%초필%약물불량반응
Somatoform disorder%Duloxetine combined use of quetiapine%Anxiety%Adverse drug reactions
目的：比较分析度罗西汀联合喹硫平治疗躯体形式障碍的疗效及不良反应。方法：选择2011年6月～2014年10月我院就诊的63名躯体形式障碍患者，随机分为两组，研究组以度罗西汀联合喹硫平进行治疗，对照组单用度罗西汀治疗，疗程均为8周。治疗前与治疗后第2周、4周、8周分别采用汉密尔顿焦虑量表（HAMA）评定患者的焦虑及躯体性焦虑情况；并在第2周、第8周采用抗抑郁药不良反应评定量表（SERS）评定不良反应。结果：治疗后两组HAMA总分及躯体性焦虑因子评分均显著降低，差异显著（P<0.05），联合应用喹硫平组下降更为明显，治愈率高于单用度罗西汀组（16.7%，41.4%），两组间差异有统计学意义（P<0.05）。且联合应用喹硫平组在治疗2周后起效快于单用度罗西汀组，差异显著（P<0.05）。两组间不良反应均表现较轻，大多出现在治疗早期，经对症治疗逐渐缓解。结论：度罗西汀联合喹硫平治疗躯体形式障碍较单用度罗西汀组疗效显著，起效快，且不良反应发生率低。
目的：比較分析度囉西汀聯閤喹硫平治療軀體形式障礙的療效及不良反應。方法：選擇2011年6月～2014年10月我院就診的63名軀體形式障礙患者，隨機分為兩組，研究組以度囉西汀聯閤喹硫平進行治療，對照組單用度囉西汀治療，療程均為8週。治療前與治療後第2週、4週、8週分彆採用漢密爾頓焦慮量錶（HAMA）評定患者的焦慮及軀體性焦慮情況；併在第2週、第8週採用抗抑鬱藥不良反應評定量錶（SERS）評定不良反應。結果：治療後兩組HAMA總分及軀體性焦慮因子評分均顯著降低，差異顯著（P<0.05），聯閤應用喹硫平組下降更為明顯，治愈率高于單用度囉西汀組（16.7%，41.4%），兩組間差異有統計學意義（P<0.05）。且聯閤應用喹硫平組在治療2週後起效快于單用度囉西汀組，差異顯著（P<0.05）。兩組間不良反應均錶現較輕，大多齣現在治療早期，經對癥治療逐漸緩解。結論：度囉西汀聯閤喹硫平治療軀體形式障礙較單用度囉西汀組療效顯著，起效快，且不良反應髮生率低。
목적：비교분석도라서정연합규류평치료구체형식장애적료효급불량반응。방법：선택2011년6월～2014년10월아원취진적63명구체형식장애환자，수궤분위량조，연구조이도라서정연합규류평진행치료，대조조단용도라서정치료，료정균위8주。치료전여치료후제2주、4주、8주분별채용한밀이돈초필량표（HAMA）평정환자적초필급구체성초필정황；병재제2주、제8주채용항억욱약불량반응평정량표（SERS）평정불량반응。결과：치료후량조HAMA총분급구체성초필인자평분균현저강저，차이현저（P<0.05），연합응용규류평조하강경위명현，치유솔고우단용도라서정조（16.7%，41.4%），량조간차이유통계학의의（P<0.05）。차연합응용규류평조재치료2주후기효쾌우단용도라서정조，차이현저（P<0.05）。량조간불량반응균표현교경，대다출현재치료조기，경대증치료축점완해。결론：도라서정연합규류평치료구체형식장애교단용도라서정조료효현저，기효쾌，차불량반응발생솔저。
Objietive:To study the effect and Adverse reactions of Duloxetine augmented with Quetiapine in the treatment of? somatoform disorder.Methods:Respectively using Hamilton anxiety scale and the scale for assessment of antidepressant drug adverse reactions, analysis of 63 somatoform disorde patients who clinic in our hospital during 2011.06-2014.10. The patients Were randomly divided into Duloxetine group, Duloxetine augmented with Quetiapine group, a course of 8 weeks. Assessed of the curative effect through the change of patients’ anxiety scores and somatic anxiety scores by Hamilton anxiety scale (HAMA), before and after taking medicine 2、4、8 weeks,and observed the main adverse drug reactions after had the medicine 2、8 weeks by antidepressant drug adverse reaction rating scale (SERS).Results:The HAMA total scores and somatic anxiety scores after treatment,the two groups of patients were significantly lower, with significant difference(P<0.05),the combined use of quetiapine group decreased more obviously,and the cure rate was higher than the group that singly applicated with Duloxetine(16.7%,16.7%),there are significant difference between the two groups(P<0.05). And combined use of quetiapine group in treatment two weeks later they work faster than the singly applicated with Duloxetine group, with significant difference (P<0.05).Adverse reactions between the two groups are lighter,mostly occur in the treatment of early, after the symptomatic treatment gradually ease.Conclusion:The curative effect of Duloxetine combined use of quetiapine in the treatment of somatoform disorder was good and work fast, no increased in adverse reactions.
