CAJ | 학술논문

利用简单易得的原料设计并合成了新型的 N-芳基取代的吲哚衍生物；通过 C－H 活化反应策略，发展了乙酸铜促进的吲哚衍生物的分子内 C－H 活化／胺化反应，获得了具有潜在生物活性的新型吲哚稠杂环化合物。研究了反应的底物适用范围，通过 X-射线单晶衍射确定了化合物的晶体结构，提出了可能的反应机理。
이용간단역득적원료설계병합성료신형적 N-방기취대적신타연생물；통과 C－H 활화반응책략，발전료을산동촉진적신타연생물적분자내 C－H 활화／알화반응，획득료구유잠재생물활성적신형신타주잡배화합물。연구료반응적저물괄용범위，통과 X-사선단정연사학정료화합물적정체결구，제출료가능적반응궤리。
A series of N-aryl-substituted indole derivatives were designed and synthesized from readily avail-able starting materials.Some novel indole-fused heterocycles compounds with potential biological activities were obtained through intramolecular C-H activation/amination reaction of N-aryl-substituted indoles derivatives promoted by Cu(OAc)2 · H2 O.The application scope of substrates were studied,the crystal structure of new cyclic product was characterized by X-ray diffraction,and the mechanism was proposed.