CAJ | 학술논문

猪戊型肝炎是一种新的人畜共患病,其病原戊型肝炎病毒(hepatitis E virus, HEV)是无囊膜的RNA病毒,主要通过消化道进行传播。研究发现,世界上许多国家的猪群中普遍存在 HEV 抗体及猪戊型肝炎病毒RNA 携带。与患病猪群密切接触、食用未煮熟的猪肉或猪肉制品、被污染的水源及水产品,这些因素都可增加戊型肝炎的患病风险。猪作为戊型肝炎病毒的宿主,不仅对公共卫生和食品安全构成威胁,同时对人类戊型肝炎流行病学有很大的影响。本文简要介绍了 HEV的病原学以及抗原抗体检测方法,包括血清学、免疫学及分子生物学方法等,并对国内外开展的戊型肝炎检测技术的研究进展进行综述。
저무형간염시일충신적인축공환병,기병원무형간염병독(hepatitis E virus, HEV)시무낭막적RNA병독,주요통과소화도진행전파。연구발현,세계상허다국가적저군중보편존재 HEV 항체급저무형간염병독RNA 휴대。여환병저군밀절접촉、식용미자숙적저육혹저육제품、피오염적수원급수산품,저사인소도가증가무형간염적환병풍험。저작위무형간염병독적숙주,불부대공공위생화식품안전구성위협,동시대인류무형간염류행병학유흔대적영향。본문간요개소료 HEV적병원학이급항원항체검측방법,포괄혈청학、면역학급분자생물학방법등,병대국내외개전적무형간염검측기술적연구진전진행종술。
ABSTRACT:Swine hepatitis E is a new kind of zoonosis, with the pathogen of hepatitis E virus (HEV). Non-enveloped hepatitis E virus has a single stranded positive-sense RNA genome. Fecal-oral transmission is the usual route of hepatitis E. The studies have shown that the existing of HEV antibodies and swine HEV RNA among pigs through the world. It will increase the risk of infecting hepatitis E when people come into contact with sick pigs, or eating undercooked pork and products, contaminated water and fishery products. Pigs as the host of HEV, not only pose a threat to public health and food safety, but also greatly influence the epidemiology of human hepatitis E. The etiology and detection methodology of HEV were introduced in this paper, including serology, immunology and molecular biology method. The progress in research of detection of HEV was reviewed in detail, including the detection of antigen and antibody.