CAJ | 학술논문

目的：探讨血清鸢尾素水平与糖尿病肾病（DN）及其临床代谢参数的关系。方法54例2型糖尿病患者中，合并DN 8例（ DN组），肾小球滤过率（ GFR）正常者46例（对照组）。检测两组身高、体质量、BMI、血压、骨骼肌量、体脂肪量、体脂百分比、血糖、血脂、肝肾功能指标及血清鸢尾素水平；采用Pearson相关分析法及多元线性回归分析法分析鸢尾素水平与代谢参数的相关性。结果 DN组肌酐水平高于对照组，鸢尾素水平低于对照组（ P均＜0．05）。鸢尾素水平与HbA1C（r＝0．269，P＜0．05）、GFR（r＝0．327，P＜0．05）、收缩压（β＝0．485，P＜0．05）、TC （β＝1．737，P＜0．05）呈正相关关系，与LDL-C呈负相关关系（β＝－1．370，P＜0．05）。结论 DN患者血清鸢尾素水平降低，其可能参与了DN糖脂代谢紊乱、肾功能损伤的发生。
목적：탐토혈청연미소수평여당뇨병신병（DN）급기림상대사삼수적관계。방법54례2형당뇨병환자중，합병DN 8례（ DN조），신소구려과솔（ GFR）정상자46례（대조조）。검측량조신고、체질량、BMI、혈압、골격기량、체지방량、체지백분비、혈당、혈지、간신공능지표급혈청연미소수평；채용Pearson상관분석법급다원선성회귀분석법분석연미소수평여대사삼수적상관성。결과 DN조기항수평고우대조조，연미소수평저우대조조（ P균＜0．05）。연미소수평여HbA1C（r＝0．269，P＜0．05）、GFR（r＝0．327，P＜0．05）、수축압（β＝0．485，P＜0．05）、TC （β＝1．737，P＜0．05）정정상관관계，여LDL-C정부상관관계（β＝－1．370，P＜0．05）。결론 DN환자혈청연미소수평강저，기가능삼여료DN당지대사문란、신공능손상적발생。
Objective To investigated the association among serum irisin level , diabetic nephropathy ( DN) and it′s clinical metabolic parameters .Methods A total of 54 subjects with diagnosed type 2 diabetes were involved in this study , including 8 DN patients (DN group) and 46 normal glomerular filtration rate (GFR) patients (control group).Height , weight, body mass index (BMI), blood pressure, skeletal muscle, body fat mass, body fat percentage, blood glucose , se-rum lipid, hepatic function , kidney function and irisin level were measured .The association between serum irisin and met-abolic parameters was analyzed by Pearson bivariate correlation and multiple linear regression analysis .Results Compared with control group, the serum creatinine level of DN group increased and the irisin level decreased (P<0.05).Irisin level was positively correlated with HbA1C(r=0.269,P<0.05), GFR(r=0.327, P<0.05), systolic pressure(β=0.485, P<0.05), total cholesterol(β=1.737, P<0.05).Irisin level was negatively correlated with LDL-C(β=-1.370, P<0.05).Conclusions Serum irisin level was lower in DN patients , which indicated that irisin may be involved in the me-tabolism disorder of glucose and lipid as well as the kidney impairment of DN .