CAJ | 학술논문

采用溶剂研磨法制备了难溶性药物来那度胺与烟酰胺的共晶，并使用差示扫描量热分析（ DSC）、热重分析（TGA）、X射线粉末衍射（PXRD）和红外光谱（IR）对其进行了表征。此外，采用密度泛函理论（DFT）和B3LYP/6-31G（d）基组，通过高斯计算对来那度胺和烟酰胺之间的作用力进行了理论分析。计算和实验结果均表明了来那度胺与烟酰胺之间可形成共晶（1：1）。
채용용제연마법제비료난용성약물래나도알여연선알적공정，병사용차시소묘량열분석（ DSC）、열중분석（TGA）、X사선분말연사（PXRD）화홍외광보（IR）대기진행료표정。차외，채용밀도범함이론（DFT）화B3LYP/6-31G（d）기조，통과고사계산대래나도알화연선알지간적작용력진행료이론분석。계산화실험결과균표명료래나도알여연선알지간가형성공정（1：1）。
A kind of cocrystal of lenalidomide and nicotinamide was prepared by solvent-drop grinding and characterized by use of FTIR,DSC,TGA and PXRD. Gaussian was also introduced to assess the theoreti-cal possibility at B3LYP/6-31G(d). Both computational and experimental results have showed that lena-lidomide and nicotinamide can form a kind of cocrystal in a molar ratio of 1 :1 .