CAJ | 학술논문

目的：利用18氟-脱氧葡萄糖 micro-PET(18F-FDG micro-PET)影像学技术观察正常组小鼠,模型组和电针组老年痴呆模型SAMP8小鼠(快速老化小鼠)大脑海马区的葡萄糖代谢情况。方法随机挑选6月龄正常组SAMR1小鼠4只,痴呆模型组和电针组 SAMP8小鼠各4只,通过2%异氟烷吸入麻醉后,从尾静脉弹丸式注射放射性示踪剂18F-FDG,每例约14.8～16.5MBq,摄取1 h后进行10 min micro-PET图像采集。计算并比较各组小鼠每克脑的海马组织18F-FDG的摄取率。结果电针组小鼠每克脑组织18F-FDG的摄取率高于正常组和模型组。结论电针能明显提高SAMP8小鼠脑18F-FDG的摄取及每克脑组织的摄取率,并可能通过影响脑葡萄糖代谢而发挥神经保护作用。
목적：이용18불-탈양포도당 micro-PET(18F-FDG micro-PET)영상학기술관찰정상조소서,모형조화전침조노년치태모형SAMP8소서(쾌속노화소서)대뇌해마구적포도당대사정황。방법수궤도선6월령정상조SAMR1소서4지,치태모형조화전침조 SAMP8소서각4지,통과2%이불완흡입마취후,종미정맥탄환식주사방사성시종제18F-FDG,매례약14.8～16.5MBq,섭취1 h후진행10 min micro-PET도상채집。계산병비교각조소서매극뇌적해마조직18F-FDG적섭취솔。결과전침조소서매극뇌조직18F-FDG적섭취솔고우정상조화모형조。결론전침능명현제고SAMP8소서뇌18F-FDG적섭취급매극뇌조직적섭취솔,병가능통과영향뇌포도당대사이발휘신경보호작용。
Objective To observe cerebral hippocampus glucose metabolism using 18F-FDG micro-PET as an imaging technique in a normal group of mice, and model and electroacupuncture groups of SAMP8 mice with senile dementia (rapid aging mice). Method Four 6-month-old SAMR1 mice were picked at random out of the normal group and every four 6-month-old SAMP8 mice, out of the model and electroacupuncture groups respectively. Each of them was anesthetized by inhalation of 2% isoflurane and then given a bolus injection of radioactive tracer 18F-FDG 14.8~16.5 MBq through the tail vein. After one hour of the uptake, a PET scan was performed for 10 min. Hippocampus 18F-FDG uptake rate per gram of brain was calculated in every group of mice and the uptake rates were compared between the groups.Result The 18F-FDG uptake rate per gram of brain tissue was higher in the electroacupuncture group of mice than in the normal and model groups.Conclusion Electroacupuncture can markedly increase cerebral 18F-FDG uptake and the uptake rate per gram of brain tissue in SAMP8 mice. It may play a neuroprotective role through its influence on cerebral glucose metabolism.