CAJ | 학술논문

铜离子螯合剂能与铜离子发生螯合作用进而清除人体内过多的铜，临床常用于治疗威尔逊疾病。目前，国内对该类药物药代动力学的相关报道较少，且铜离子螯合剂在治疗过程中常出现不同类型、程度不一的不良反应。本文主要介绍这类药物的药代动力学和不良反应研究资料，为临床合理用药提供参考。
동리자오합제능여동리자발생오합작용진이청제인체내과다적동，림상상용우치료위이손질병。목전，국내대해류약물약대동역학적상관보도교소，차동리자오합제재치료과정중상출현불동류형、정도불일적불량반응。본문주요개소저류약물적약대동역학화불량반응연구자료，위림상합리용약제공삼고。
Copper chelators,such as penicillamine,trientine and dimercaptosuccinic acid,ets,has been commonly used in treatment of patients with Wilson's disease(WD). We summarized some different types of adverse reactions often occurredin clini-cal practice and introduced some pharmacokinetic data,which might be useful for clinicians.