CAJ | 학술논문

原发性胆汁性肝硬化（PBC）属于一种病因未明的自身免疫性疾病。Th17细胞及Treg细胞是CD4+T细胞的两个亚群，分别起着抑制、促进炎症反应的作用，它们在分化和功能上相互抑制。PBC作为肝脏特异性的自身免疫性疾病，诸多研究提示Th17和Treg细胞数量及相关细胞因子在PBC患者中较健康者有差别，但其具体机制仍不清楚。近年来，它们在PBC发病中的变化越来越成为研究的热点。本文重点介绍Treg细胞和Th17细胞的研究现状及其在PBC发病机制中的作用。
원발성담즙성간경화（PBC）속우일충병인미명적자신면역성질병。Th17세포급Treg세포시CD4+T세포적량개아군，분별기착억제、촉진염증반응적작용，타문재분화화공능상상호억제。PBC작위간장특이성적자신면역성질병，제다연구제시Th17화Treg세포수량급상관세포인자재PBC환자중교건강자유차별，단기구체궤제잉불청초。근년래，타문재PBC발병중적변화월래월성위연구적열점。본문중점개소Treg세포화Th17세포적연구현상급기재PBC발병궤제중적작용。
Primary biliary cirrhosis (PBC) is a kind of autoimmune diseases with unknown etiology. Th17 cells and Treg cells are two subpopulations of CD4+T cells,plays suppression of,or promotion of inflammatory reactions respectively. They inhibit each other in the differentiation and function. Many studies suggest that Th17 and Treg cells,and related cytokines differ in PBC patients from in healthy persons,but the exact mechanism remains unclear. In recent years,their changes in the pathogenesis of PBC has become a hot topic. This review focuses on the research about Treg cells and Th17 cells and their roles in the patho-genesis of PBC.