CAJ | 학술논문

血清HBsAg阴性，但肝组织或血清HBV DNA长期存在，这种状态被称为隐匿性HBV感染（OBI）。由于实际HBV流行率和病毒流行株的地域性差异、所选取的研究人群的差异和不同检测方法的敏感性和特异性的差异，不同研究所得到的O-BI的流行率有很大的差别。OBI的形成机制尚未完全阐明，可能有多种病毒学因素、宿主因素参与其中。OBI能通过输血、分娩和肝移植等方式进行传播，引起新发感染。当宿主免疫功能下降或应用免疫抑制性药物时，OBI可以复燃，恢复经典的血清学表现。OBI引起的轻微但持续的坏死性炎症可以促进肝脏疾病的进展，并且可以通过直接或者间接的机制增加肿瘤的发生风险。临床上需要建立更敏感的检测方法诊断OBI，以减少OBI相关的潜在威胁，帮助医师合理采取治疗措施，延缓病情进展。
혈청HBsAg음성，단간조직혹혈청HBV DNA장기존재，저충상태피칭위은닉성HBV감염（OBI）。유우실제HBV류행솔화병독류행주적지역성차이、소선취적연구인군적차이화불동검측방법적민감성화특이성적차이，불동연구소득도적O-BI적류행솔유흔대적차별。OBI적형성궤제상미완전천명，가능유다충병독학인소、숙주인소삼여기중。OBI능통과수혈、분면화간이식등방식진행전파，인기신발감염。당숙주면역공능하강혹응용면역억제성약물시，OBI가이복연，회복경전적혈청학표현。OBI인기적경미단지속적배사성염증가이촉진간장질병적진전，병차가이통과직접혹자간접적궤제증가종류적발생풍험。림상상수요건립경민감적검측방법진단OBI，이감소OBI상관적잠재위협，방조의사합리채취치료조시，연완병정진전。
Occult hepatitis B virus (HBV) infection (OBI) is defined as the status with persistent serum HBsAg negative, but with serum/intrahepatic HBV DNA positive. Due to the differences in prevalence of HBV infection,prevalent viral strains, study samples,as well as sensitivity and specificity of methodology,the available data of OBI prevalence quite varied. The patho-genesis of OBI has not been fully elucidated. It is a complex process involving multiple virological and host factors. OBI can be transmitted through blood transfusion,parturition and liver transplantation to cause de novo infection. Immune dysfunction andap-plication of immunosuppressive agents can lead to OBI reactivation and recurrence of typical serological evidence. The slight but persistent necro-inflammation can promote the progression of liver disease and increase the risk of tumorigenesis. In clinic,more sensitive detection methods are needed for diagnosis of OBI to reduce OBI-related potential threat and help clinicians to take reasonable managements to slow the progression of the disease.