CAJ | 학술논문

目的：通过醛糖还原酶高通量模型对中药方剂平糖舒目散的筛选，探寻其治疗糖尿病的作用机制。方法：用高通量醛糖还原酶筛模型来筛选平糖舒目散，研究方剂平糖舒目散对醛糖还原酶的抑制作用。结果：平糖舒目散对醛糖还原酶有较强的抑制作用，其半数抑制浓度是0.8g／L。结论：中药方剂平糖舒目散治疗糖尿病慢性并发症的作用机制之一是抑制醛糖还原酶活性。
목적：통과철당환원매고통량모형대중약방제평당서목산적사선，탐심기치료당뇨병적작용궤제。방법：용고통량철당환원매사모형래사선평당서목산，연구방제평당서목산대철당환원매적억제작용。결과：평당서목산대철당환원매유교강적억제작용，기반수억제농도시0.8g／L。결론：중약방제평당서목산치료당뇨병만성병발증적작용궤제지일시억제철당환원매활성。
Objective:To explore the mechanism of Chinese prescription Pingtang Shumu powder in treating diabetes by screening it in high-flux aldose reductase models.Methods:High-flux aldose reductase model was used to screen Pingtang Shumu powder,so as to study on its exhibition effect on aldose reductase.Results:Pingtang Shumu powder had strong exhibition effect on aldose re-ductase with the Icso of 0.8g/L.Conclusion:The mechanism of Chinese prescription of Pingtang Shumu powder treating chronic complications of diabetes is to exhibit the activity of aldose reductase.