CAJ | 학술논문

目的：观察局部给予5-羟色胺（5-HT）对大鼠舌下神经核兴奋性的影响。方法8只成年雄性SD大鼠，置入微透析导管于其舌下神经核，通过微透析导管向舌下神经核泵入新鲜人工脑脊液（ ACSF ）、新鲜5-HT溶液，监测未给药、泵入新鲜ACSF、泵入新鲜5-HT溶液时的颏舌肌肌电，利用区间测量方法计算颏舌肌肌电面积。结果未给药、泵入ACSF、泵入5-HT时大鼠的颏舌肌肌电的面积分别为（0．811±0．122）、（0．859±0．121）、（1．247±0．122） mV· s，前两者比较，P＝0．081；前两者与后者比较，P＝0．003、0．005。结论5-HT可以提高舌下神经核的兴奋性。
목적：관찰국부급여5-간색알（5-HT）대대서설하신경핵흥강성적영향。방법8지성년웅성SD대서，치입미투석도관우기설하신경핵，통과미투석도관향설하신경핵빙입신선인공뇌척액（ ACSF ）、신선5-HT용액，감측미급약、빙입신선ACSF、빙입신선5-HT용액시적해설기기전，이용구간측량방법계산해설기기전면적。결과미급약、빙입ACSF、빙입5-HT시대서적해설기기전적면적분별위（0．811±0．122）、（0．859±0．121）、（1．247±0．122） mV· s，전량자비교，P＝0．081；전량자여후자비교，P＝0．003、0．005。결론5-HT가이제고설하신경핵적흥강성。
Objective To observe the effect of local 5-hydroxytryptamine (5-HT) on neuronal excitability of rat hypo-glossal nucleus .Methods Eight adult male SD rats were selected .Micro dialysis catheter was placed into the hypoglossal nucleus, through which, we pumped the fresh artificial cerebrospinal fluid (ACSF), fresh 5-HT solution into the hypoglos-sal nucleus .Then we monitored genioglossus electromyography at the moment of no drug delivery , pumping fresh ACSF , and pumping fresh 5-HT solution .The genioglossus electromyography area was calculated by interval measurement method . Results The genioglossus electromyography chin area at the time of no medicine administration , pumping ACSF , and pumping into 5-HT was respectively (0.811 ±0.122), (0.859 ±0.121), (1.247 ±0.122) mV· s, when we compared the former two, P=0.081;when we compared the first two with the latter two , P=0.003, 0.005.Conclusion 5-HT can improve the excitability of hypoglossal nucleus .