CAJ | 학술논문

目的：观察有大肠癌家族史的大肠多发性腺瘤组织中中抑癌基因APC和凋亡抑制基因Survivin的表达变化，并探讨其意义。方法采用免疫组织化学方法检测20例大肠腺癌、32例有大肠癌家族史的大肠多发性腺瘤、32例无大肠癌家族史的大肠多发性腺瘤、20例正常大肠组织中APC及Survivin蛋白的表达情况。结果在大肠腺癌、有大肠癌家族史的大肠多发性腺瘤、无大肠癌家族史的大肠多发性腺瘤和正常组织中APC蛋白的阳性表达率分别为20．0％、56．3％、65．6％和95．0％。 Survivin蛋白的阳性表达率分别为75．0％、40．6％、28．1％和0。有大肠癌家族史的大肠多发性腺瘤组APC蛋白阳性表达强度低于无家族史的大肠多发性腺瘤组，Survivin蛋白阳性强度高于无家族史的大肠多发性腺瘤组（P均＜0．05）。结论与正常大肠组织相比，大肠多发性腺瘤组织中APC蛋白表达下调，Survivin蛋白表达上调；与无大肠癌家族者相比，有大肠癌家族史的大肠多发性腺瘤组织中APC蛋白表达更低，Survivin蛋白表达更高。
목적：관찰유대장암가족사적대장다발성선류조직중중억암기인APC화조망억제기인Survivin적표체변화，병탐토기의의。방법채용면역조직화학방법검측20례대장선암、32례유대장암가족사적대장다발성선류、32례무대장암가족사적대장다발성선류、20례정상대장조직중APC급Survivin단백적표체정황。결과재대장선암、유대장암가족사적대장다발성선류、무대장암가족사적대장다발성선류화정상조직중APC단백적양성표체솔분별위20．0％、56．3％、65．6％화95．0％。 Survivin단백적양성표체솔분별위75．0％、40．6％、28．1％화0。유대장암가족사적대장다발성선류조APC단백양성표체강도저우무가족사적대장다발성선류조，Survivin단백양성강도고우무가족사적대장다발성선류조（P균＜0．05）。결론여정상대장조직상비，대장다발성선류조직중APC단백표체하조，Survivin단백표체상조；여무대장암가족자상비，유대장암가족사적대장다발성선류조직중APC단백표체경저，Survivin단백표체경고。
Objective To investigate the expressions and significances of tumor suppressor gene APC and apoptosis inhibiting gene Survivin in colorectal multiple adenomas with a family history of colorectal cancer .Methods The expres-sions of APC and Survivin gene were detected by immunohistochemical staining among the cases from 20 colorectal adeno-carcinomas , 32 colorectal multiple adenomas with a family history of colorectal cancer , 32 colorectal multiple adenomas without a family history of colorectal cancer , 20 normal colorectal mucosas .Results There had differences in positive rate for expressions of APC and Survivin among the colorectal adenocarcinomas , the colorectal multiple adenomas with a family history of colorectal cancer , the colorectal multiple adenomas without a family history of colorectal cancer , the normal color-ectal mucosas, the positive rate of APC protein was 20.0%, 56.3%, 65.6%, 95.0%, respectively (P<0.01).The positive rate of Survivin protein was 75.0%, 40.6%, 28.1%, 0%, respectively (P<0.01).In colorectal multiple ade-nomas with a family history of colorectal cancer , the positive intensity of APC protein was lower and the positive intensity of Survivin protein was higher than that in the colorectal multiple adenomas without a family history of colorectal cancer ( all P<0.05).Conclusion Compared with the normal colorectal mucosas , the APC protein down-regulated expression and Survivin protein up-regulated expression in colorectal multiple adenomas .In colorectal multiple adenomas with a family his-tory of colorectal cancer , the expression of APC protein was lower and the expression of Survivin protein was higher than that in the colorectal multiple adenomas without a family history of colorectal cancer .