CAJ | 학술논문

目的：探讨EGFR蛋白在大肠癌组织中的表达及临床意义。方法使用免疫组化SP法检测EGFR蛋白在大肠癌组织中的表达。结果 EGFR蛋白阳性表达率在大肠癌组明显高于癌旁正常粘膜组（P＜0.05）；EGFR蛋白阳性表达与大肠癌淋巴结转移及临床分期（TNM）有关（P＜0.05），而与大肠癌患者的性别、年龄及分化程度无关（P＜0.05）。结论 EGFR蛋白的阳性表达与大肠癌的发生、发展、侵袭及转移有一定关系。
목적：탐토EGFR단백재대장암조직중적표체급림상의의。방법사용면역조화SP법검측EGFR단백재대장암조직중적표체。결과 EGFR단백양성표체솔재대장암조명현고우암방정상점막조（P＜0.05）；EGFR단백양성표체여대장암림파결전이급림상분기（TNM）유관（P＜0.05），이여대장암환자적성별、년령급분화정도무관（P＜0.05）。결론 EGFR단백적양성표체여대장암적발생、발전、침습급전이유일정관계。
Objective To investigate the expression of EGFR protein in colorectal cancer tissues and its clinical signiifcance. Methods Using the expression of SP immunohistochemical method to detect EGFR protein in colorectal carcinoma tissues. Results EGFR protein positive expression rate was significantly higher than that of adjacent normal mucosa group in colorectal cancer group (P<0.05), the expression of EGFR protein in colorectal cancer and lymph node metastasis and clinical staging (TNM) on (P<0.05), but not in patients with colorectal cancer of sex, age and degree of differentiation (P<0.05). Conclusion Positive expression of EGFR protein has certain relationship with the occurrence and development, invasion and metastasis of colorectal cancer.