CAJ | 학술논문

脑缺血性疾病是神经系统常见病及多发病，目前已成为危害我国中老年人群人身健康和生命的主要原因。近年的研究发现，中医活血化瘀疗法能改善脑微循环，阻滞神经细胞的凋亡和坏死，但中医益气活血法对神经细胞的修复作用尚未见深入研究。骨髓间充质干细胞（BMSCs）是一种非造血干细胞，在微环境作用下能向各个胚层的细胞分化，具有取材方便、免疫源性低等特点，近年来成为细胞、基因工程和再生医学研究的热点。近几年，基质金属蛋白酶（MMPs）已被视为缺血性脑卒中急性期的标志物之一，更成为治疗脑卒中的新靶点。
뇌결혈성질병시신경계통상견병급다발병，목전이성위위해아국중노년인군인신건강화생명적주요원인。근년적연구발현，중의활혈화어요법능개선뇌미순배，조체신경세포적조망화배사，단중의익기활혈법대신경세포적수복작용상미견심입연구。골수간충질간세포（BMSCs）시일충비조혈간세포，재미배경작용하능향각개배층적세포분화，구유취재방편、면역원성저등특점，근년래성위세포、기인공정화재생의학연구적열점。근궤년，기질금속단백매（MMPs）이피시위결혈성뇌졸중급성기적표지물지일，경성위치료뇌졸중적신파점。
Cerebral ischemic disease was common in nervous system. It severely damaged health and life in elderly. Recent studies have shown that Huoxue Huayu therapy could improve cerebral LDF and forbid apoptosis and necrosis of nerve cell. Yiqi Huoxue therapy was not deeply researched in restoration of nerve cells. BMSCs was a kind of non-hematopoietic stem cells, it could differentiate into various germ layers in the microenvironment. In recent years, it became a hot spot of cell, gene engineering and regenerative medicine based on the features of easily obtained and low immunogenicity, etc. In recent years, MMPs was regarded as the sign of acute phase of ischemic stroke and new target in the treatment of stroke.