动物医学进展
動物醫學進展
동물의학진전
PROGRESS IN VETERINARY MEDICINE
2015年
3期
107-111
,共5页
李杨%吴丽娜%李英伦%高祝%荣茜
李楊%吳麗娜%李英倫%高祝%榮茜
리양%오려나%리영륜%고축%영천
黄曲霉毒素B1%肝癌%细胞色素P450%酶活性%中药
黃麯黴毒素B1%肝癌%細胞色素P450%酶活性%中藥
황곡매독소B1%간암%세포색소P450%매활성%중약
AFB1%liver cancer%CYP450%enzymatic activity%Chinese medicine
黄曲霉毒素Bl (AFBl)会对人和动物的肝脏产生损伤,还会引发肝癌。它还与其他致肝癌的因素,如乙型肝炎病毒(HBV)的慢性感染等协同作用而促进肝癌的发生和发展。AFBl可能通过影响DNA修复系统、药物代谢酶系统及细胞色素P450(CYP)代谢酶基因的异常表达导致肝癌的发生。有研究报道,许多中药能通过影响细胞色素P450酶而起到保护肝脏的作用。论文就黄曲霉毒素 B1对肝损伤过程中 P450代谢酶活性变化及一些中药显著降低AFB1诱发肝癌发生率的机制进行综述。
黃麯黴毒素Bl (AFBl)會對人和動物的肝髒產生損傷,還會引髮肝癌。它還與其他緻肝癌的因素,如乙型肝炎病毒(HBV)的慢性感染等協同作用而促進肝癌的髮生和髮展。AFBl可能通過影響DNA脩複繫統、藥物代謝酶繫統及細胞色素P450(CYP)代謝酶基因的異常錶達導緻肝癌的髮生。有研究報道,許多中藥能通過影響細胞色素P450酶而起到保護肝髒的作用。論文就黃麯黴毒素 B1對肝損傷過程中 P450代謝酶活性變化及一些中藥顯著降低AFB1誘髮肝癌髮生率的機製進行綜述。
황곡매독소Bl (AFBl)회대인화동물적간장산생손상,환회인발간암。타환여기타치간암적인소,여을형간염병독(HBV)적만성감염등협동작용이촉진간암적발생화발전。AFBl가능통과영향DNA수복계통、약물대사매계통급세포색소P450(CYP)대사매기인적이상표체도치간암적발생。유연구보도,허다중약능통과영향세포색소P450매이기도보호간장적작용。논문취황곡매독소 B1대간손상과정중 P450대사매활성변화급일사중약현저강저AFB1유발간암발생솔적궤제진행종술。
Aflatoxin Bl (AFBl)would damage the liver of human and animals,even lead to serious liver cancer.The synergistic interaction of AFBl and HBV promotes hepatocarcinogenesis.AFBl may lead to liver cancer by influencing genes of the DNA repair system,drug metabolic enzyme system and cytochrome P450 (CYP450)metabolic enzyme.Many researches have reported that Chinese medicine through the cyto-chrome P450 enzymes play a role in protecting the liver.In this paper,the effects of aflatoxin B1 on CYP450 metabolic enzymatic activity in liver injury,and mechanisms of some Chinese medicines significant-ly reducing the incidence of liver cancer by AFB1 were reviewed.