CAJ | 학술논문

观察不同剂量纳米氧化铈颗粒染毒后对大鼠血清超氧化物歧化酶（SOD）活力和丙二醛（MDA）含量的影响及大鼠肺组织GRP78蛋白表达情况，探讨其导致肺损伤的作用机制。将粒径为35 nm±3 nm的纳米氧化铈颗粒悬液以不同剂量（100 mg／kg、400 mg／kg）给大鼠气管滴注，染毒28 d后，测定大鼠血清中SOD活力、MDA含量及肺组织GRP78蛋白表达情况。与对照组相比，高低剂量纳米氧化铈染毒组大鼠血清中SOD活力及MDA含量均无明显改变（P＞0．05），GRP78蛋白表达均显著增高（P＜0．05）。纳米氧化铈染毒大鼠所致肺损伤与内质网应激有关，与氧化应激的关系有待进一步研究。
관찰불동제량납미양화시과립염독후대대서혈청초양화물기화매（SOD）활력화병이철（MDA）함량적영향급대서폐조직GRP78단백표체정황，탐토기도치폐손상적작용궤제。장립경위35 nm±3 nm적납미양화시과립현액이불동제량（100 mg／kg、400 mg／kg）급대서기관적주，염독28 d후，측정대서혈청중SOD활력、MDA함량급폐조직GRP78단백표체정황。여대조조상비，고저제량납미양화시염독조대서혈청중SOD활력급MDA함량균무명현개변（P＞0．05），GRP78단백표체균현저증고（P＜0．05）。납미양화시염독대서소치폐손상여내질망응격유관，여양화응격적관계유대진일보연구。
To investigate the effects on the levels of serum SOD and MDA in rats and the expression of GRP78 in lungs of rats treated with different doses nano CeO2 ,and study the mechanism of pulmonary inj ury induced by nano CeO2 ,the suspension of nano CeO2 (35 nm±3 nm)of different doses (400 mg/kg,100 mg/kg)were administrated via intratracheal instillation in rats.After 28 days,the levels of serum SOD and MDA and the expression of GRP78 were observed.In comparison with the control,the levels of serum SOD and MDA treated with different doses of nano CeO2 had no significant change(P>0.05),the expression of GRP78 in all groups increased significantly(P<0.05).Pulmo-nary inj ury induced by nano CeO2 in rats was related to endoplasmic reticulum stress,and the relationship between pul-monary inj ury and oxidative stress should be further researched.