CAJ | 학술논문

旨在研究五加芪水煎液对小鼠免疫功能的影响。将6周龄雌性昆明小鼠随机分成正常小鼠组（正常对照，高、中、低剂量组）和免疫抑制小鼠组（正常对照，Hy＋蒸馏水组，Hy＋高剂量组，Hy＋中剂量组，Hy＋低剂量组），连续灌胃7 d，测定小鼠免疫器官指数、碳粒廓清指数、血清溶血素水平和脾内抗体形成细胞（PFC）的变化。结果表明，高、中剂量五加芪水煎液可显著提高正常小鼠脾指数（P＜0．01），各给药组均能显著提高正常小鼠胸腺指数（P＜0．01或P＜0．05）和碳粒廓清指数（P＜0．01），高剂量五加芪水煎液能显著提高正常小鼠血清溶血素水平（P＜0．01），各给药组均对正常小鼠脾内抗体形成细胞数量无明显影响（P＞0．05）。各剂量五加芪水煎液均使免疫抑制小鼠脾指数、胸腺指数、碳粒廓清指数、血清溶血素水平和脾内抗体形成细胞数量显著提高（与Hy＋蒸馏水组相比，P＜0．01或P＜0．05），且恢复至正常水平（与正常组相比，P＞0．05）。
지재연구오가기수전액대소서면역공능적영향。장6주령자성곤명소서수궤분성정상소서조（정상대조，고、중、저제량조）화면역억제소서조（정상대조，Hy＋증류수조，Hy＋고제량조，Hy＋중제량조，Hy＋저제량조），련속관위7 d，측정소서면역기관지수、탄립곽청지수、혈청용혈소수평화비내항체형성세포（PFC）적변화。결과표명，고、중제량오가기수전액가현저제고정상소서비지수（P＜0．01），각급약조균능현저제고정상소서흉선지수（P＜0．01혹P＜0．05）화탄립곽청지수（P＜0．01），고제량오가기수전액능현저제고정상소서혈청용혈소수평（P＜0．01），각급약조균대정상소서비내항체형성세포수량무명현영향（P＞0．05）。각제량오가기수전액균사면역억제소서비지수、흉선지수、탄립곽청지수、혈청용혈소수평화비내항체형성세포수량현저제고（여Hy＋증류수조상비，P＜0．01혹P＜0．05），차회복지정상수평（여정상조상비，P＞0．05）。
The aim of this study was to investigate the effect of Astragalus and Acanthopanax decoction on immune function in mice.6 week old female Kunming mice were randomly divided into normal mice groups (control group,high-,mediate-,low dose group)and immunosuppressive mice groups (normal control, Hy+ distilled water group,Hy+ high dose group,Hy+ mediate dose group,Hy+ low dose group). The mice were intragastrically administrated for 7 days,and the immune organ index,the carbon clearance index,the levels of serum hemolysin and spleen antibody forming cell (PFC)were tested.The result showed that the high,middle dose Astragalus and Acanthopanax decoction can significantly improve the normal mice spleen index (P<0.01),all treated groups could significantly increase the thymus index (P<0.01or P<0.05)and the carbon clearance index(P<0.01)in normal mice,there was significantly in-crease of the level of serum hemolysin in high dose group,the three treated groups had no significant effect on PFC in normal mice;Each dose Astragalus and Acanthopanax decoction can improve the immune spleen index,thymus index,the carbon clearance index,the levels of serum hemolysin and PFC significantly (com-pared with Hy+ distilled water group P<0.01 or P<0.05),and recovered to the normal level (compared with normal control group P>0.05).