CAJ | 학술논문

目的：探讨六味地黄丸与银杏叶片联合应用对2型糖尿病（type 2 diabetes mellitus, T2DM）患者糖尿病并发症的影响。方法收集2011年3－9月南京医科大学附属南京医院内分泌科收治的T2DM患者78例，按随机数字表法分为2组，每组39例。常规治疗组口服降糖药或胰岛素控制，中药治疗组在常规治疗基础上加用六味地黄丸和银杏叶片。分别于治疗前，治疗后12个月、36个月监测颈动脉内膜中层厚度（intima-media thickness, IMT）、双足振动感觉阈值（vibration perception threshold, VPT）及糖尿病视网膜病等情况。结果治疗后12个月，中药治疗组左足VPT明显低于常规治疗组[(13.98±4.38)V比(18.70±2.43)V；t＝2.764，P＝0.008]。治疗后36个月，中药治疗组颈动脉 IMT[左侧：(0.70±0.10)mm比(0.81±0.16)mm，t＝3.120，P＝0.003；右侧：(0.73±0.12)mm比(0.81±0.17)mm，t＝2.286，P＝0.026]；VPT[左足：(14.82±6.45)V 比(20.63±9.75)V，t＝2.714，P＝0.009；右足：(16.73±7.10)V 比(20.73±10.35)V，t＝2.001，P＝0.048]，以及糖尿病视网膜病发生率[35.9%(14/39)比53.8%(21/39)；χ2＝5.804， P＝0.016]均明显低于常规治疗组。结论六味地黄丸联合银杏叶片可有效减缓T2DM患者糖尿病并发症的进展。
목적：탐토륙미지황환여은행협편연합응용대2형당뇨병（type 2 diabetes mellitus, T2DM）환자당뇨병병발증적영향。방법수집2011년3－9월남경의과대학부속남경의원내분비과수치적T2DM환자78례，안수궤수자표법분위2조，매조39례。상규치료조구복강당약혹이도소공제，중약치료조재상규치료기출상가용륙미지황환화은행협편。분별우치료전，치료후12개월、36개월감측경동맥내막중층후도（intima-media thickness, IMT）、쌍족진동감각역치（vibration perception threshold, VPT）급당뇨병시망막병등정황。결과치료후12개월，중약치료조좌족VPT명현저우상규치료조[(13.98±4.38)V비(18.70±2.43)V；t＝2.764，P＝0.008]。치료후36개월，중약치료조경동맥 IMT[좌측：(0.70±0.10)mm비(0.81±0.16)mm，t＝3.120，P＝0.003；우측：(0.73±0.12)mm비(0.81±0.17)mm，t＝2.286，P＝0.026]；VPT[좌족：(14.82±6.45)V 비(20.63±9.75)V，t＝2.714，P＝0.009；우족：(16.73±7.10)V 비(20.73±10.35)V，t＝2.001，P＝0.048]，이급당뇨병시망막병발생솔[35.9%(14/39)비53.8%(21/39)；χ2＝5.804， P＝0.016]균명현저우상규치료조。결론륙미지황환연합은행협편가유효감완T2DM환자당뇨병병발증적진전。
Objective To investigate the effects ofLiuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets on diabetic complications in patients with type 2 diabetes mellitus (T2DM). Methods Seventy-eight patients with T2DM were randomized into a TCM treatment group and a conventional treatment group by random number table method, 39 in each group. The patients in the conventional treatment group were regularly using antihyperglycemic drugs or insulin. On the basis of conventional treatment group, the patients in the TCM treatment group were additionally treated withLiuwei-Dihuang Pills and Ginkgo Biloba Leaves Extract Tablets. Intima-media thickness (IMT) of internal carotid artery, vibration perception threshold (VPT) and diabetic retinopathy in both groups were detected before the treatment, 12 and 36 months after the treatment.Results The VPT in the left foot 12 months after the treatment in the TCM treatment group were significantly lower than that in the conventional treatment group (13.98 ±4.38 Vvs. 18.70 ±2.43 V;t=2.764, P=0.008). IMT of internal carotid artery (left: 0.81 ± 0.16 mmvs.0.70 ± 0.10 mm,t=3.120,P=0.003; right: 0.81 ± 0.17 mmvs. 0.73 ± 0.12 mm,t=2.286,P=0.026), VPT (left foot: 14.82 ± 6.45 Vvs. 20.63 ± 9.75 V,t=2.714, P=0.009; right foot: 16.73 ± 7.10 Vvs. 20.73 ± 10.35 V,t=2.001,P=0.048) and incidence of diabetic retinopathy (35.9%vs. 53.8%;χ2=5.804,P=0.016) 36 months after the treatment in the TCM treatment group were significantly lower than those in the conventional treatment group.ConclusionsLiuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets can effectively reduce the progression of diabetic complications in patients with T2DM.