国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2015年
3期
247-250
,共4页
心肌梗死%心率%收缩张力%舒张张力%参麦注射液%心得安
心肌梗死%心率%收縮張力%舒張張力%參麥註射液%心得安
심기경사%심솔%수축장력%서장장력%삼맥주사액%심득안
Myocardial infarction%Heart rate%Isometric tension%Diastolic tension%Shenmaiinjection%Propranolol
目的：观察参麦注射液对心肌梗死模型大鼠离体心脏舒缩功能的作用。方法将32只大鼠按随机数字表法分为对照组、心得安组、参麦联合心得安组、参麦组，每组8只。采用左侧冠状动脉前降支结扎方法制备心肌梗死模型。于造模成功后3 d断头取心脏组织，采用Langendorff离体心脏灌流法记录各组心肌梗死模型大鼠离体心脏在灌流前5 min及灌流后0.5、1、2 h的收缩张力（IT）、舒张张力（DT）、心率（HR）、左室最大上升/下降速率（±LVdp/dtmax）。结果在灌流给药后0.5、1、2 h，心得安组 IT[(2.01±0.02)g、(1.52±0.01)g、(1.53±0.02)g]，HR[(326±32)次/min、(331±41)次/min、(307±37)次/min]、±dp/dtmax[(4012±193)mmHg/s、(3729±174)mmHg/s、(3631±123)mmHg/s；(3565±202)mmHg/s、(3632±154)mmHg/s、(3601±129)mmHg/s]较对照组明显降低（P＜0.05）；参麦组IT[(2.71±0.10)g、(3.74±0.04)g、(3.17±0.01)g]、HR[(491±46)次/min、(527±52)次/min、(519±49)次/min],+LV dp/dtmax[(5690±2403)mmHg/s、(5739±219)mmHg/s、(5825±186)mmHg/s]较对照组明显增高（P＜0.05）。参麦联合心得安组IT、DT、HR及±LVdp/dtmax变化不明显（P＞0.05）。结论参麦注射液可增强心肌梗死模型大鼠离体心脏心肌收缩力，心得安可阻断参麦注射液的强心效应，提示参麦注射液可能具有β-受体激动剂效应。
目的：觀察參麥註射液對心肌梗死模型大鼠離體心髒舒縮功能的作用。方法將32隻大鼠按隨機數字錶法分為對照組、心得安組、參麥聯閤心得安組、參麥組，每組8隻。採用左側冠狀動脈前降支結扎方法製備心肌梗死模型。于造模成功後3 d斷頭取心髒組織，採用Langendorff離體心髒灌流法記錄各組心肌梗死模型大鼠離體心髒在灌流前5 min及灌流後0.5、1、2 h的收縮張力（IT）、舒張張力（DT）、心率（HR）、左室最大上升/下降速率（±LVdp/dtmax）。結果在灌流給藥後0.5、1、2 h，心得安組 IT[(2.01±0.02)g、(1.52±0.01)g、(1.53±0.02)g]，HR[(326±32)次/min、(331±41)次/min、(307±37)次/min]、±dp/dtmax[(4012±193)mmHg/s、(3729±174)mmHg/s、(3631±123)mmHg/s；(3565±202)mmHg/s、(3632±154)mmHg/s、(3601±129)mmHg/s]較對照組明顯降低（P＜0.05）；參麥組IT[(2.71±0.10)g、(3.74±0.04)g、(3.17±0.01)g]、HR[(491±46)次/min、(527±52)次/min、(519±49)次/min],+LV dp/dtmax[(5690±2403)mmHg/s、(5739±219)mmHg/s、(5825±186)mmHg/s]較對照組明顯增高（P＜0.05）。參麥聯閤心得安組IT、DT、HR及±LVdp/dtmax變化不明顯（P＞0.05）。結論參麥註射液可增彊心肌梗死模型大鼠離體心髒心肌收縮力，心得安可阻斷參麥註射液的彊心效應，提示參麥註射液可能具有β-受體激動劑效應。
목적：관찰삼맥주사액대심기경사모형대서리체심장서축공능적작용。방법장32지대서안수궤수자표법분위대조조、심득안조、삼맥연합심득안조、삼맥조，매조8지。채용좌측관상동맥전강지결찰방법제비심기경사모형。우조모성공후3 d단두취심장조직，채용Langendorff리체심장관류법기록각조심기경사모형대서리체심장재관류전5 min급관류후0.5、1、2 h적수축장력（IT）、서장장력（DT）、심솔（HR）、좌실최대상승/하강속솔（±LVdp/dtmax）。결과재관류급약후0.5、1、2 h，심득안조 IT[(2.01±0.02)g、(1.52±0.01)g、(1.53±0.02)g]，HR[(326±32)차/min、(331±41)차/min、(307±37)차/min]、±dp/dtmax[(4012±193)mmHg/s、(3729±174)mmHg/s、(3631±123)mmHg/s；(3565±202)mmHg/s、(3632±154)mmHg/s、(3601±129)mmHg/s]교대조조명현강저（P＜0.05）；삼맥조IT[(2.71±0.10)g、(3.74±0.04)g、(3.17±0.01)g]、HR[(491±46)차/min、(527±52)차/min、(519±49)차/min],+LV dp/dtmax[(5690±2403)mmHg/s、(5739±219)mmHg/s、(5825±186)mmHg/s]교대조조명현증고（P＜0.05）。삼맥연합심득안조IT、DT、HR급±LVdp/dtmax변화불명현（P＞0.05）。결론삼맥주사액가증강심기경사모형대서리체심장심기수축력，심득안가조단삼맥주사액적강심효응，제시삼맥주사액가능구유β-수체격동제효응。
ObjectiveTo observe the effect ofShenmai injection on isolated cardiac systolic and diastolic function in myocardial infarction rats.Methods32 rats were randomly divided into a control group, a propranolol group, aShenmai + propranolol group and aShenmai group. The myocardial infarction models were made by ligating the left anterior descending coronary artery of rats .The heart was taken from myocardial infarction rat after 3 days. The indexes of Isometric tension (IT), Diastolic tension (DT), heart rate (HR), the maximum pressure ascending and descending rate of left ventricle (± LVdp/dtmax) (mmHg/s) were recorded by using Langendorff isolated heart perfusion technique at 5min before and 0.5 h, 1 h, 2 h after perfusion.ResultsCompared with the control group, the IT (2.01 ± 0.02 g, 1.52 ± 0.01 g, 1.53 ± 0.02 g), the HR (326 ± 32 time/min, 331 ± 41 time/min, 307 ± 37 time/min) and the ±LVdp/dtmax (4 012 ± 193 mmHg/s, 3 729 ± 174 mmHg/s, 3 631 ± 123 mmHg/s; 3 565 ± 202 mmHg/s, 3 632 ± 154 mmHg/s, 3 601 ± 129 mmHg/s) were apparently decreased in the propranolol group at 0.5 h, 1 h, 2 h after perfusion, and the differences were statistically significant (P<0.05). Compared with the control group, the IT (2.71 ± 0.10 g, 3.74 ± 0.04 g, 3.17 ± 0.01 g), the HR (491 ± 46 time/min, 527 ± 52 time/min, 519 ± 49 time/min) and the +LV dp/dtmax (5 690 ± 2 403 mmHg/s, 5 739 ± 219 mmHg/s, 5 825 ± 186 mmHg/s) were distinctly increased in theShenmaigroup at 0.5 h, 1 h, and 2 h after perfusion, and the differences were statistically significant (P<0.05). While the IT, DT, HR and ±LVdp/dtmax in theShenmai + propranolol group had no significant effect compared with the control group(P> 0.05).ConclusionsShenmaiinjection can improve myocardial contractility in isolated heart of myocardial infarction rats, however, propranolol can completely block the strong heart effect ofShenmaiinjection. This suggests thatShenmai injection has a beta receptor agonist effect.
