CAJ | 학술논문

目的：观察西咪替丁佐治小儿过敏性紫癜对心率及 QT间期、心率校正的 QT 间期（linear corrected QT，QTLc）的影响并探讨其临床意义。方法采用随机对照的研究方法，选择腹型过敏性紫癜患儿83例，随机分为观察组和对照组。对照组37例，给予地塞米松、维生素C、钙剂综合治疗；观察组46例，在综合治疗基础上加用西咪替丁。观测心电图心率及 QT间期、QTLc情况。结果用药后心率及 QT间期、QTLc两组间比较差异有统计学意义，在综合治疗的基础上加用西咪替丁的观察组较对照组心率减慢，QT间期及 QTLc延长。结论临床小儿使用西咪替丁治疗期间须监测心电图心率及 QT间期、QTLc变化，避免室性心律失常的发生。
목적：관찰서미체정좌치소인과민성자전대심솔급 QT간기、심솔교정적 QT 간기（linear corrected QT，QTLc）적영향병탐토기림상의의。방법채용수궤대조적연구방법，선택복형과민성자전환인83례，수궤분위관찰조화대조조。대조조37례，급여지새미송、유생소C、개제종합치료；관찰조46례，재종합치료기출상가용서미체정。관측심전도심솔급 QT간기、QTLc정황。결과용약후심솔급 QT간기、QTLc량조간비교차이유통계학의의，재종합치료적기출상가용서미체정적관찰조교대조조심솔감만，QT간기급 QTLc연장。결론림상소인사용서미체정치료기간수감측심전도심솔급 QT간기、QTLc변화，피면실성심률실상적발생。
ABSTRACT:Objective To observe the effect of cimetidine on the heart rate,QT interval and linear corrected QT (QTLc)of children with allergic purpura.Methods Randomized controlled trial was conducted in this study.A total of 83 children with abdominal allergic purpura were randomly divided into two groups:control group (n=37)and observation group (n=46 ).All patients received combined modality therapy with dexamethasone,vitamin C and calcium supplements,while patients in the observation group were given cimetidine additionally.Heart rate,QT interval and QTLc were monitored during the treatment.Results There were statistical significance in heart rate,QT interval and QTLc between two groups. Compared with the control group, the heart rate in observation group decreased,but QT interval and QTLc prolonged.Conclusion During the treatment with cimetidine for the children with allergic purpura,heart rate,QT interval and QTLc should be monitored in order to avoid ventricular arrhythmia.