CAJ | 학술논문

目的：探讨血清对氧磷酶1（paraoxonase 1，PON1）活性与2型糖尿病患者颈动脉粥样硬化的关系。方法2型糖尿病患者117例，根据颈动脉彩色多普勒超声测定结果，分为无动脉粥样硬化（AS）组38例，AS组79例；选择同期健康体检者75例（对照组），测量血压、体质量指数（BMI）、腰臀比、空腹血糖、餐后2小时血糖、糖化血红蛋白、总胆固醇、甘油三酯（TG）、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血尿酸等各项指标，同时测定血清 PON1活性。分析血清PON1活性与颈动脉粥样硬化的关系。结果与对照组比较，糖尿病组血清 PON1（240．0±15．6） kU／L vs （229．5±19．6）kU／L、AS发生率（44．0％ vs 67．5％）、BMI（24．3±3．6）kg／m2 vs （25．8±3．2）kg／m2、腰臀比（0．89±0．05）vs （0．93±0．06）、收缩压（131．0±8．3）mmHg（1 mmHg＝0．133 kPa）vs （134．0±8．8）mmHg、TG （1．8±0．8）mmol／L vs （2．1±1．3）mmol／L等比较差异有统计学意义（P＜0．05）；AS组血清 PON1活性明显低于非AS组（235．5±19．9）kU／L vs （226．7±18．9）kU／L（P＜0．05）；糖尿病患者血清PON1活性与年龄呈负相关（r＝－0．382，P＜0．01），与血清TG水平呈正相关（r＝0．223，P＜0．05）。结论2型糖尿病患者血清PON1活性显著下降，PON1活性降低与颈动脉粥样硬化发生密切相关。
목적：탐토혈청대양린매1（paraoxonase 1，PON1）활성여2형당뇨병환자경동맥죽양경화적관계。방법2형당뇨병환자117례，근거경동맥채색다보륵초성측정결과，분위무동맥죽양경화（AS）조38례，AS조79례；선택동기건강체검자75례（대조조），측량혈압、체질량지수（BMI）、요둔비、공복혈당、찬후2소시혈당、당화혈홍단백、총담고순、감유삼지（TG）、고밀도지단백담고순、저밀도지단백담고순、혈뇨산등각항지표，동시측정혈청 PON1활성。분석혈청PON1활성여경동맥죽양경화적관계。결과여대조조비교，당뇨병조혈청 PON1（240．0±15．6） kU／L vs （229．5±19．6）kU／L、AS발생솔（44．0％ vs 67．5％）、BMI（24．3±3．6）kg／m2 vs （25．8±3．2）kg／m2、요둔비（0．89±0．05）vs （0．93±0．06）、수축압（131．0±8．3）mmHg（1 mmHg＝0．133 kPa）vs （134．0±8．8）mmHg、TG （1．8±0．8）mmol／L vs （2．1±1．3）mmol／L등비교차이유통계학의의（P＜0．05）；AS조혈청 PON1활성명현저우비AS조（235．5±19．9）kU／L vs （226．7±18．9）kU／L（P＜0．05）；당뇨병환자혈청PON1활성여년령정부상관（r＝－0．382，P＜0．01），여혈청TG수평정정상관（r＝0．223，P＜0．05）。결론2형당뇨병환자혈청PON1활성현저하강，PON1활성강저여경동맥죽양경화발생밀절상관。
ABSTRACT:Objective To explore the correlation of serum paraoxonase 1(PON1)activity with the incidence of carotid atherosclerosis(AS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 117 patients with T2DM,including 38 cases with carotid atherosclerosis and 79 cases without carotid atherosclerosis,were enrolled in this study.Also,75 healthy individuals without diabetes served as control group.Blood pressure,body mass index (BMI),waist-hip ratio,fasting blood glucose,2-hour post-meal blood glucose,HbA1 c,total cholesterol,triglyceride (TG),high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,uric acid and serum PON1 activity of two groups were determined and compared.Then,the relationship between the serum PON1 activity and the incidence of carotid atherosclerosis were analyzed.Results Serum PON1 activity in T2DM group was lower than that in control group (229.5±19.6 kU/L vs 240.0±15.6 kU/L,P<0.05).The incidence of carotid atherosclerosis,BMI,waist-hip ratio,systolic pressure and TG in T2DM group were prominently higher than those in control group,respectively 67.5% vs 44.0%,25.8±3.2 kg/m2 vs 24.3±3.6 kg/m2 ,0.93±0.06 vs 0.89±0.05,134.0±8.8 mmHg vs 131.0± 8.3 mmHg and 2.1±1.3 mmol/L vs 1.8±0.8 mmol/L(P<0.05).Among the patients with T2DM,serum PON1 activity in AS group was significantly lower than that in non-AS group (226.7±18.9 kU/L vs 235.5±19.9 kU/L,P<0.05).Serum PON1 activity was negatively correlated with the age of the patients (r=-0.382,P <0.01),but positively correlated with TG (r=0.223,P <0.05).Conclusion Serum PON1 activity decreases significantly in patients with T2DM,which is closely associated with the incidence of carotid atherosclerosis.