CAJ | 학술논문

目的：：观察达比加群酯(dabigatran)在治疗小面积肺栓塞(单个肺叶阻塞)中的疗效并讨论其安全性。方法：108例符合小面积肺栓塞诊断标准的患者,随机分为治疗组(56例)和对照组(52例)。治疗组患者口服达比加群酯110mg,2次/日,服用3个月；对照组患者口服华法令5 mg,服用3个月。通过回访、复查,对两组在症状控制、主要终点事件及不良反应发生的情况等方面做出评价疗效。结果：达比加群酯抗凝有效(P<0.05),出血并发症与华法令比较差异无显著性(P>0.05)。结论：达比加群酯在治疗小面积肺栓塞中的抗凝效果明显有效。
목적：：관찰체비가군지(dabigatran)재치료소면적폐전새(단개폐협조새)중적료효병토론기안전성。방법：108례부합소면적폐전새진단표준적환자,수궤분위치료조(56례)화대조조(52례)。치료조환자구복체비가군지110mg,2차/일,복용3개월；대조조환자구복화법령5 mg,복용3개월。통과회방、복사,대량조재증상공제、주요종점사건급불량반응발생적정황등방면주출평개료효。결과：체비가군지항응유효(P<0.05),출혈병발증여화법령비교차이무현저성(P>0.05)。결론：체비가군지재치료소면적폐전새중적항응효과명현유효。
Objective:To investigate the effect of dabigatran on small area of PE(with single lobe obstruc-ted)and its safety.Methods:Select 108 cases who are up to the diagnisis criteria of small area PE and ran-domly divide them into the treatment group (56 cases)and control group(52 cases).in the treatment group, the patients orally took 110 mg of dabigatran twice a day for three monthes while in the control group,the patients orally took 110mg of warfarin for 3 monthes .Pay a return visit to them and review the condition ,e-valuate the effect according to the control of symptoms ,the occurrence of main outcome events and adverse reaction and other aspects.Results:It was effective to anticoagulate with dabigatran (P<0.05),compared with warfarin,there was no obvious difference on bleeding symptoms.Conclusion:Dabigatran is effective to treat small area PE,and its anticoagulatnt effect is obvious.