CAJ | 학술논문

目的：探讨乳腺癌组织中Pokemon和p53蛋白的表达及其相关性，并分析其与乳腺癌患者临床病理特征的关系。方法采用免疫组化En Vision法检测90例乳腺癌和相应癌旁组织中Pokemon和p53蛋白的表达情况。结果乳腺癌组织中Pokemon和p53蛋白表达阳性率均明显高于癌旁组织（均P＜0.01）；Pokemon和p53蛋白的表达与乳腺癌患者临床分期及淋巴结转移均有关（均P＜0.01），而与患者年龄、肿瘤大小、组织学类型及分级均无关（均P＞0.05）。Spearman相关分析显示在乳腺癌组织中，Pokemon和p53蛋白表达呈正相关（P＜0.01）。结论 Pokemon和p53蛋白异常表达可能与乳腺癌的发生、发展有关，联合检测两者对评估乳腺癌生物学行为及预后具有较重要的临床意义。
목적：탐토유선암조직중Pokemon화p53단백적표체급기상관성，병분석기여유선암환자림상병리특정적관계。방법채용면역조화En Vision법검측90례유선암화상응암방조직중Pokemon화p53단백적표체정황。결과유선암조직중Pokemon화p53단백표체양성솔균명현고우암방조직（균P＜0.01）；Pokemon화p53단백적표체여유선암환자림상분기급림파결전이균유관（균P＜0.01），이여환자년령、종류대소、조직학류형급분급균무관（균P＞0.05）。Spearman상관분석현시재유선암조직중，Pokemon화p53단백표체정정상관（P＜0.01）。결론 Pokemon화p53단백이상표체가능여유선암적발생、발전유관，연합검측량자대평고유선암생물학행위급예후구유교중요적림상의의。
Objective To investigate the expression of Pokemon and p53 in breast cancer and its clinicopathologic significance. Methods The expression of Pokemon and p53 was detected in 90 cases of breast cancer and pericancerous breast tissues by En Vision immunohistochemical method. Results The positive rates of Pokemon and p53 in cancer tissue was significantly higher than those in pericancerous breast tissue (P<0.01). The expression of Pokemon and p53 proteins was corre-lated with clinical stage and lymph node metastasis (P<0.01);but not correlated with age, tumor size, histological types and clin-ical grades(P>0.05). Spearman correlation analysis showed that there was a positive correlation between Pokemon and p53 ex-pression in breast cancer (P<0.01). Conclusion Pokemon and p53 proteins are highly expressed in breast cancer, which may be associated with its biological behavior and prognosis of patients.