CAJ | 학술논문

目的：检测c- Met蛋白在甲状腺癌及癌旁甲状腺组织中的表达，并分析c- Met蛋白表达与甲状腺乳头状癌患者临床病理特征的关系。方法采用免疫组织化学En Vision二步法检测81例甲状腺癌组织及52例癌旁甲状腺组织中c- Met蛋白的表达。结果甲状腺癌和癌旁甲状腺组织中c- Met蛋白阳性率分别为46.9%（38/81）和7.7%（4/52），两者比较有统计学差异（P＜0.01）。其中甲状腺乳头状癌中c- Met蛋白阳性率50.8%（31/61），髓样癌中阳性率60.0%（3/5），均高于滤泡癌26.7%（4/15），但均无统计学差异（均P＞0.05）。甲状腺乳头状癌c- Met蛋白表达与患者各项临床病理特征均无相关性（均P＞0.05）。结论甲状腺癌中c- Met表达增强，其高表达可能与甲状腺癌发生相关，有望成为抗甲状腺癌治疗的一个潜在靶点。
목적：검측c- Met단백재갑상선암급암방갑상선조직중적표체，병분석c- Met단백표체여갑상선유두상암환자림상병리특정적관계。방법채용면역조직화학En Vision이보법검측81례갑상선암조직급52례암방갑상선조직중c- Met단백적표체。결과갑상선암화암방갑상선조직중c- Met단백양성솔분별위46.9%（38/81）화7.7%（4/52），량자비교유통계학차이（P＜0.01）。기중갑상선유두상암중c- Met단백양성솔50.8%（31/61），수양암중양성솔60.0%（3/5），균고우려포암26.7%（4/15），단균무통계학차이（균P＞0.05）。갑상선유두상암c- Met단백표체여환자각항림상병리특정균무상관성（균P＞0.05）。결론갑상선암중c- Met표체증강，기고표체가능여갑상선암발생상관，유망성위항갑상선암치료적일개잠재파점。
Objective To investigate the expression of c- Met protein in thyroid carcinoma and its clinicopathological significance in papil ary thyroid carcinoma. Methods The immunohistochemical En Vision method was used to evaluate the ex-pression of c- Met in 81 specimens of thyroid cancer tissues and 52 specimens of adjacent thyroid tissues. Results The ex-pression of c- Met protein in thyroid cancer was significantly higher than that in adjacent thyroid tissue (46.9%vs 7.7%, P<0.01). There were no significant differences in c- Met expression rates among papil ary carcinoma (50.8%, 31/61) , medul ary carcinoma (60.0%, 3/5) and fol icular carcinoma (26.7%, 4/15) (P>0.05). c- Met protein expression was not correlated with the clinicopatho-logical features of thyroid papil ary carcinoma (P>0.05). Conclusion c- Met expression is increased in thyroid cancer, it may be involved in the tumorigenesis of thyroid and might be a potential therapeutic target.