CAJ | 학술논문

目的：分析出生后24 h凝血功能异常新生儿的临床表现及影响因素。方法收集169例住院新生儿的凝血功能检查结果及临床资料，其中符合接受抗凝治疗的患儿共76例，另93例新生儿作为对照，分析凝血功能异常组与对照组凝血功能的差异，并分析凝血障碍相关危险因素。结果凝血功能异常组的宫内窘迫、肺炎、酸中毒及低体温的比例均高于对照组，差异均有统计学意义(χ2=6.18~38.01，P<0.05)。多元logistic回归分析显示，宫内窘迫(OR=12.06，95%CI：3.71~39.25)、肺炎(OR=4.10，95%CI：1.43~11.74)为新生儿凝血功能异常发生的独立危险因素(P均<0.05)。结论宫内窘迫、肺炎是新生儿凝血功能异常的危险因素，提前预防有助于减少新生儿出血性疾病的发生。
목적：분석출생후24 h응혈공능이상신생인적림상표현급영향인소。방법수집169례주원신생인적응혈공능검사결과급림상자료，기중부합접수항응치료적환인공76례，령93례신생인작위대조，분석응혈공능이상조여대조조응혈공능적차이，병분석응혈장애상관위험인소。결과응혈공능이상조적궁내군박、폐염、산중독급저체온적비례균고우대조조，차이균유통계학의의(χ2=6.18~38.01，P<0.05)。다원logistic회귀분석현시，궁내군박(OR=12.06，95%CI：3.71~39.25)、폐염(OR=4.10，95%CI：1.43~11.74)위신생인응혈공능이상발생적독립위험인소(P균<0.05)。결론궁내군박、폐염시신생인응혈공능이상적위험인소，제전예방유조우감소신생인출혈성질병적발생。
Objective To investigate the clinical manifestations and inlfuencing factors in the newborns with coagulant function abnormality in the ifrst 24 hours after birth. Methods The coagulation test results and clinical data of 169 newborns in our hospital were studied. Children receiving anticoagulant therapy were assigned as coagulation abnormalities group (n=76) and other healthy newborns were assigned as control group (n=93). The differences of coagulation function between the two groups were analyzed and the inlfuencing factors of coagulation abnormalities were explored. Results The proportions of fetal distress, pneumonia, acidosis and hypothermia of coagulation abnormalities group were signiifcantly higher than that of the control group (χ2=6.18–38.01, P<0.05). Logistic regression analysis showed that fetal distress (OR=12.06, 95%CI:3.71–39.25), pneumonia (OR=4.10, 95%CI: 1.43–11.74) were the high risk factors for coagulant function abnormality, and the differences were statistically signiifcant (both P<0.05). Conclusions Fetal distress, pneumonia were the high risk factors for coagulant function abnormality. Early prevention can help to reduce the incidence of neonatal hemorrhagic disease.