临床儿科杂志
臨床兒科雜誌
림상인과잡지
2015年
2期
109-112
,共4页
张东伟%张光莉%李俊奇%李颖%张慧%刘茹%刘莎%罗征秀
張東偉%張光莉%李俊奇%李穎%張慧%劉茹%劉莎%囉徵秀
장동위%장광리%리준기%리영%장혜%류여%류사%라정수
特异质%呼出气一氧化氮%支气管哮喘%慢性持续期%儿童
特異質%呼齣氣一氧化氮%支氣管哮喘%慢性持續期%兒童
특이질%호출기일양화담%지기관효천%만성지속기%인동
atopy%exhaled nitric oxide%asthma%chronic persistent stage%child
目的：评估特异质对慢性持续期哮喘儿童呼出气一氧化氮(FeNO)水平的影响。方法选取同时完成皮肤点刺试验和FeNO 检测的慢性持续期哮喘患儿52例，按皮肤点刺试验结果分为非特异质组和特异质组，按有无合并过敏性鼻炎分为鼻炎组和无鼻炎组；另选择78例健康儿童作为对照组，比较各组FeNO水平；并比较32例予吸入型糖皮质激素治疗3个月患儿的FeNO水平变化。结果40例特异质组、12例非特异质组和对照组的FeNO水平差异有统计学意义(H=33.29，P=0.000)；特异质组FeNO水平高于对照组和非特异质组，差异有统计学意义(P<0.05)。11例无鼻炎组、41例鼻炎组和对照组的FeNO水平差异有统计学意义(H=30.63，P=0.000)；鼻炎组FeNO水平高于对照组，差异有统计学意义(P<0.05)；鼻炎组与无鼻炎组差异无统计学意义(P>0.05)。特异质组患儿FeNO水平与屋尘螨、粉尘螨皮肤点刺致敏风团直径无相关性(r=2.05、1.58，P均>0.05)。32例患儿经吸入糖皮质激素治疗3个月后FeNO水平显著下降，与其治疗前第一次检测结果比较，差异有统计学意义(Z=2.05，P=0.041)。结论特异质对慢性持续期哮喘儿童FeNO水平有重要影响，吸入糖皮质激素可显著降低致敏哮喘儿童FeNO水平。
目的：評估特異質對慢性持續期哮喘兒童呼齣氣一氧化氮(FeNO)水平的影響。方法選取同時完成皮膚點刺試驗和FeNO 檢測的慢性持續期哮喘患兒52例，按皮膚點刺試驗結果分為非特異質組和特異質組，按有無閤併過敏性鼻炎分為鼻炎組和無鼻炎組；另選擇78例健康兒童作為對照組，比較各組FeNO水平；併比較32例予吸入型糖皮質激素治療3箇月患兒的FeNO水平變化。結果40例特異質組、12例非特異質組和對照組的FeNO水平差異有統計學意義(H=33.29，P=0.000)；特異質組FeNO水平高于對照組和非特異質組，差異有統計學意義(P<0.05)。11例無鼻炎組、41例鼻炎組和對照組的FeNO水平差異有統計學意義(H=30.63，P=0.000)；鼻炎組FeNO水平高于對照組，差異有統計學意義(P<0.05)；鼻炎組與無鼻炎組差異無統計學意義(P>0.05)。特異質組患兒FeNO水平與屋塵螨、粉塵螨皮膚點刺緻敏風糰直徑無相關性(r=2.05、1.58，P均>0.05)。32例患兒經吸入糖皮質激素治療3箇月後FeNO水平顯著下降，與其治療前第一次檢測結果比較，差異有統計學意義(Z=2.05，P=0.041)。結論特異質對慢性持續期哮喘兒童FeNO水平有重要影響，吸入糖皮質激素可顯著降低緻敏哮喘兒童FeNO水平。
목적：평고특이질대만성지속기효천인동호출기일양화담(FeNO)수평적영향。방법선취동시완성피부점자시험화FeNO 검측적만성지속기효천환인52례，안피부점자시험결과분위비특이질조화특이질조，안유무합병과민성비염분위비염조화무비염조；령선택78례건강인동작위대조조，비교각조FeNO수평；병비교32례여흡입형당피질격소치료3개월환인적FeNO수평변화。결과40례특이질조、12례비특이질조화대조조적FeNO수평차이유통계학의의(H=33.29，P=0.000)；특이질조FeNO수평고우대조조화비특이질조，차이유통계학의의(P<0.05)。11례무비염조、41례비염조화대조조적FeNO수평차이유통계학의의(H=30.63，P=0.000)；비염조FeNO수평고우대조조，차이유통계학의의(P<0.05)；비염조여무비염조차이무통계학의의(P>0.05)。특이질조환인FeNO수평여옥진만、분진만피부점자치민풍단직경무상관성(r=2.05、1.58，P균>0.05)。32례환인경흡입당피질격소치료3개월후FeNO수평현저하강，여기치료전제일차검측결과비교，차이유통계학의의(Z=2.05，P=0.041)。결론특이질대만성지속기효천인동FeNO수평유중요영향，흡입당피질격소가현저강저치민효천인동FeNO수평。
Objective To evaluate the influence of atopy on exhaled nitric oxide in chronic persistent asthmatic children. Methods A total of 52 chronic persistent asthmatic children who completed FeNO measurements and skin prick testing were enrolled. Patients were divided into non-atopic group and atopic group by skin prick testing results, and subdivided into non-allergic rhinitis and rhinitis group according to whether combined with allergic rhinitis. At the same time 78 healthy children were chosen as control group. Moreover, 32 chronic persistent asthmatic children who completed FeNO measurements twice interval of three months were enrolled. Results The FeNO level was signiifcantly different among the atopic group (n=40), the non-atopic group (n=12) and the control group (H=33.29, P=0.000);The FeNO level was signiifcantly higher in the atopic group than that in the non-atopic group (P<0.05). And the FeNO level were signiifcantly different among the rhinitis group (n=41), the non-rhinitis group (n=11) and the control group (H=30.63, P=0.000). The FeNO level was signiifcantly higher in the rhinitis group than that in the control group (P<0.05), however there were no difference between the rhinitis group and the non-rhinitis group(P>0.05).There were no correlations between FeNO levels of chronic persistent asthmatic children and the wheal diameter of house dust mites or dust mites (r=2.05, P=0.135;r=1.58, P=0.312). Moreover, the FeNO level was signiifcantly lower after 3 months ICS treatment (z=-2.05, P=0.041). Conclusions Atopy had major inlfuence on the FeNO level of chronic persistent asthmatic children, and the FeNO level declined with the theatment of ICS.
