中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
9期
3-4,5
,共3页
未成熟卵泡抽吸术%多囊卵巢综合征%氯米酚抵抗%二甲双胍
未成熟卵泡抽吸術%多囊卵巢綜閤徵%氯米酚牴抗%二甲雙胍
미성숙란포추흡술%다낭란소종합정%록미분저항%이갑쌍고
Immature follicle aspiration%Polycystic ovary syndrome%Clomiphene resistant%Metformin
目的：探讨联合超声下未成熟卵泡抽吸术(IMFA)与二甲双胍对氯米酚抵抗的多囊卵巢综合征(PCOS)患者行促排卵前预处理对其卵巢反应性及治疗结局改善的有效性。方法92例氯米酚抵抗的PCOS患者随机分成对照组和IMFA组，每组46例。对照组服用二甲双胍及口服避孕药预处理， IMFA组在口服药物的基础上进行未成熟卵泡抽吸术，比较两组促排卵治疗结局。结果两组预处理后IMFA组促性腺激素(Gn)量低于对照组，单卵泡发生率较对照组高(P<0.05)。两组妊娠情况差异无统计学意义(P>0.05)，但IMFA组妊娠率升高，流产率降低。结论 IMFA可以有效改善氯米芬抵抗的PCOS患者的卵巢反应性， IMFA联合二甲双胍和口服避孕药在氯米芬抵抗的PCOS的治疗中提供了有效的新途径。
目的：探討聯閤超聲下未成熟卵泡抽吸術(IMFA)與二甲雙胍對氯米酚牴抗的多囊卵巢綜閤徵(PCOS)患者行促排卵前預處理對其卵巢反應性及治療結跼改善的有效性。方法92例氯米酚牴抗的PCOS患者隨機分成對照組和IMFA組，每組46例。對照組服用二甲雙胍及口服避孕藥預處理， IMFA組在口服藥物的基礎上進行未成熟卵泡抽吸術，比較兩組促排卵治療結跼。結果兩組預處理後IMFA組促性腺激素(Gn)量低于對照組，單卵泡髮生率較對照組高(P<0.05)。兩組妊娠情況差異無統計學意義(P>0.05)，但IMFA組妊娠率升高，流產率降低。結論 IMFA可以有效改善氯米芬牴抗的PCOS患者的卵巢反應性， IMFA聯閤二甲雙胍和口服避孕藥在氯米芬牴抗的PCOS的治療中提供瞭有效的新途徑。
목적：탐토연합초성하미성숙란포추흡술(IMFA)여이갑쌍고대록미분저항적다낭란소종합정(PCOS)환자행촉배란전예처리대기란소반응성급치료결국개선적유효성。방법92례록미분저항적PCOS환자수궤분성대조조화IMFA조，매조46례。대조조복용이갑쌍고급구복피잉약예처리， IMFA조재구복약물적기출상진행미성숙란포추흡술，비교량조촉배란치료결국。결과량조예처리후IMFA조촉성선격소(Gn)량저우대조조，단란포발생솔교대조조고(P<0.05)。량조임신정황차이무통계학의의(P>0.05)，단IMFA조임신솔승고，유산솔강저。결론 IMFA가이유효개선록미분저항적PCOS환자적란소반응성， IMFA연합이갑쌍고화구복피잉약재록미분저항적PCOS적치료중제공료유효적신도경。
Objective To explore the effectiveness of ultrasound immature follicle aspiration (IMFA) combined with metformin in pretreatment of clomiphene resistant polycystic ovary syndrome (PCOS) for ovarian response and improvement of treatment outcome. Methods A total of 92 patients with clomiphene resistant PCOS were randomly divided into control group and IMFA group, and each group contained 46 cases. The control group received metformin and oral contraceptive for pretreatment, and the IMFA group received additional immature follicle aspiration. Outcomes of ovulation induction were compared between the two groups. Results After pretreatment, the IMFA group had lower gonadotropin (Gn) than the control group, and its incidence of single follicle was higher than the control group (P<0.05). The difference of gestation condition between the two groups was not statistically significant (P>0.05), while the IMFA group had increased gestation rate and decreased abortion rate. Conclusion IMFA can effectively improve ovarian response in clomiphene resistant PCOS patients. Combination of IMFA, metformin and oral contraceptive provides a new method in the treatment of clomiphene resistant PCOS.
